Protein Alignment TyrR and LOC100490372

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_002937327.2
• Gene: LOC100490372 / 100490372
• XenbaseID: XB-GENE-29080159
• Length: 405
• Species: Xenopus tropicalis
• Alignment Length: 537
• Identity: 125/537 - (23%)
• Similarity: 195/537 - (36%)
• Gaps: 229/537 - (42%)

  Fly   110 LVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAV 174
            |.::.|.:.:.::.....::|.:||.:|.:..:..:||||:|..|:||||:|||||...|||.::
 Frog    49 LEIAPQQVAVGSLLTVIDLITFLGNAVVFICPVVEKRLRTVTYMFIMSLAMADLLVACLVMPFSI 113

  Fly   175 AVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMIL 239
            ...:.|.|..|...|.:|||.||:.|||||::||.||:|||.:|..|..|| ||.|:|..:||.:
 Frog   114 IYEVTGMWLFGKQFCKVWISFDVMFCTASIVTLCFISLDRYCSVVTPYHYS-KRMSRRRCIIMTV 177

  Fly   240 IVWLLALAIT-CPPMLGWYE-PG--RRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISC 300
            .:|:.:..|: .|.|.||.| ||  ..:.::|.:..|..:.|.::..:|:||..:|..:|
 Frog   178 TIWVYSSLISFLPVMQGWNEIPGVDTDNGKQCIFVTNWTFAIVASSLAFYIPFIIMCSMY----- 237

  Fly   301 VIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMM 365
                                                                             
 Frog   238 ----------------------------------------------------------------- 237

  Fly   366 LSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRA 430
                                                                 :.:.|.|.||
 Frog   238 -----------------------------------------------------FFIYRASRLK-- 247

  Fly   431 STASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSH 495
               :|.|.:.|         ||.
 Frog   248 ---ATRIVSQT---------LDL------------------------------------------ 258

  Fly   496 HHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINY 560
            |:||                     |||..:|    |:.|||.|:|:.|::..|:.||||:|:..
 Frog   259 HYHP---------------------NSKRQNN----LQLENKATRTMGIIISVFVMCWLPYFVLN 298

  Fly   561 LITPFLAEHQASQMLAKA---LTWLGWFNSAINPFIYAFYSVDFRAAFWR-LTCKR--------- 612
            ::.........|::|..|   :||||:.||.|||.:|||.:.||:.|..: |.|:|
 Frog   299 VLIAAKGTDSTSRVLVNAFKFITWLGYCNSTINPMLYAFLNRDFQRALKKLLICRRWRSQVDIGD 363

  Fly   613 -------FFSAGQKPQF 622
                   |....|.|::
 Frog   364 DMVSIVTFSKTAQDPEY 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	70/189 (37%)
		TM helix 1	118..144	CDD:320189	4/25 (16%)
		TM helix 2	151..177	CDD:320189	14/25 (56%)
		TM helix 3	189..219	CDD:320189	18/29 (62%)
		TM helix 4	232..255	CDD:320189	7/23 (30%)
		TM helix 5	272..297	CDD:320189	7/24 (29%)
		7tm_GPCRs	<533..605	CDD:475119	29/74 (39%)
		TM helix 6	539..561	CDD:320189	9/21 (43%)
		TM helix 7	573..598	CDD:320189	14/27 (52%)
LOC100490372	XP_002937327.2	7tmA_amine_R-like	58..346	CDD:320098	116/492 (24%)
		TM helix 1	58..83	CDD:320098	4/24 (17%)
		TM helix 2	90..117	CDD:320098	14/26 (54%)
		TM helix 3	128..158	CDD:320098	18/29 (62%)
		TM helix 4	170..190	CDD:320098	5/19 (26%)
		TM helix 5	214..270	CDD:320098	23/259 (9%)
		TM helix 6	271..301	CDD:320098	12/29 (41%)
		TM helix 7	311..339	CDD:320098	14/27 (52%)