Protein Alignment TyrR and adra1b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_031754536.1
• Gene: adra1b / 100488806
• XenbaseID: XB-GENE-6047336
• Length: 441
• Species: Xenopus tropicalis
• Alignment Length: 531
• Identity: 141/531 - (26%)
• Similarity: 211/531 - (39%)
• Gaps: 196/531 - (36%)

  Fly   115 QGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLI 179
            :.::|......||.|.:|||.:||::::|.::||..||..:::||:||||:...|:|.:....::
 Frog    43 RAMLLGFTLGAFISVAIIGNIMVIISVVTNKQLRIPTNYLIVNLAIADLLLSSTVLPFSATKEIV 107

  Fly   180 GSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTY----SRKRRSKRLALIMILI 240
            |.|..|.:|||:|.::|||.|||||.|||.||:|||:.|...|.|    :|||     .::.:|.
 Frog   108 GYWVFGRILCDVWAAMDVLCCTASIFSLCTISIDRYIGVRHSLRYPTIVTRKR-----TILALLG 167

  Fly   241 VWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASR 305
            ||:.:..|:..|:|||.||...|...|.......|.|||::.||:||:.|::.:|.|:..|.
 Frog   168 VWMFSTVISIGPLLGWKEPAPPDTYVCEITTEIFYAIFSSLASFYIPLIVILVMYCRVYVVA--- 229

  Fly   306 HDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSD 370
                       |:..:...|.|..|..:                        :|||
 Frog   230 -----------KRITKNLEAGVMKERMD------------------------SKEL--------- 250

  Fly   371 NCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTAST 435
                                |...||::.
 Frog   251 --------------------TLRIHCRNK------------------------------------ 259

  Fly   436 TITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPH 500
                                |...|..: :||.:.    ||:
 Frog   260 --------------------QDDSPNNS-KVQNNQ----PRS----------------------- 276

  Fly   501 YHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPF 565
                                   :||.::....:|.|..:||.||||.||.||||||   .:.|.
 Frog   277 -----------------------ALSLKLLKFSREKKAAKTLGIVVGMFILCWLPFF---TVLPL 315

  Fly   566 --LAEHQASQM-LAKALTWLGWFNSAINPFIYAFYSVDFRAAFWR-LTCK---RFFSAGQKPQF- 622
              |:||....: |.|.:.|||:|||.|||.||...|.:|:.||.| |.|:   |..||.::.|:
 Frog   316 SSLSEHLTPPVTLEKIIFWLGYFNSCINPIIYPCSSKEFKRAFIRILKCQWGNRKNSAFRRSQYR 380

  Fly   623 --PTNTMSIRR 631
              |.:|:|..|
 Frog   381 PRPGSTVSHSR 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	75/189 (40%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	10/25 (40%)
		TM helix 3	189..219	CDD:320189	19/29 (66%)
		TM helix 4	232..255	CDD:320189	5/22 (23%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	35/74 (47%)
		TM helix 6	539..561	CDD:320189	14/21 (67%)
		TM helix 7	573..598	CDD:320189	13/25 (52%)
adra1b	XP_031754536.1	7tmA_alpha1B_AR	45..358	CDD:320449	128/494 (26%)
		TM helix 1	46..72	CDD:320449	9/25 (36%)
		TM helix 2	79..105	CDD:320449	10/25 (40%)
		TM helix 3	117..147	CDD:320449	19/29 (66%)
		TM helix 4	159..182	CDD:320449	7/27 (26%)
		TM helix 5	199..228	CDD:320449	11/28 (39%)
		TM helix 6	286..316	CDD:320449	17/32 (53%)
		TM helix 7	326..351	CDD:320449	13/24 (54%)