Protein Alignment TyrR and hrh4.b2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_031760447.1
• Gene: hrh4.b2 / 100485915
• XenbaseID: XB-GENE-22168371
• Length: 390
• Species: Xenopus tropicalis
• Alignment Length: 515
• Identity: 111/515 - (21%)
• Similarity: 195/515 - (37%)
• Gaps: 169/515 - (32%)

  Fly   101 AAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLV 165
            |.....|.|.|    .|::||:.:..|::||.||||||||....:|||..:|.|:::|::||.::
 Frog    19 AGSTTQFSDAV----NILIIALISLLILLTVGGNTLVILAFFVEKRLRNQSNFFLLNLSIADFIL 79

  Fly   166 GIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRS 230
            |.|.:|..|...|.|.|.||..||.:|:.:|..:||||..::..||.||:|:||:.:.|..::..
 Frog    80 GTFAIPLYVPYLLTGKWLLGKFLCKLWLIVDYTMCTASAFNVALISWDRFLSVTQAVLYRSQQNR 144

  Fly   231 KRLALIMILIVWLLALAITCPPMLGW-YEPGRRDLRE----CRYNQNEGYVIFSAMGSFFIPMAV 290
            ....:|.:..||:|:..:..|.::.| :.|...::.|    ..:.....|::.::...|.:|:..
 Frog   145 PCRTVIKMAAVWILSFLLYGPAIIFWDFVPSTEEIPENICVAGFYYTWYYLLTASAFDFVLPLIS 209

  Fly   291 MIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQ 355
            :.:....|.|.|                 |:.:...::|.:|...|.|     :::|
 Frog   210 ISFFNLSIYCNI-----------------KKRSRRKMQNSISLPPQKS-----RKEA-------- 244

  Fly   356 TIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYE 420
                                                                             
 Frog   245 ----------------------------------------------------------------- 244

  Fly   421 LTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHG 485
                    :..|.:|.||..       |..:|.|.:|
 Frog   245 --------KLCTIATNITLQ-------SPQIDIQKKS---------------------------- 266

  Fly   486 ERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSL---SNRITSLKKENKTTQTLSIVVG 547
                           :..:..::.....|..|::.|:|..   :|:::.|.::.|..::||::|.
 Frog   267 ---------------FRRRINISCNQCFGIKSSSHNNKRSDRENNQVSDLSRDKKVAKSLSVLVC 316

  Fly   548 GFIACWLPFFINYLITPFLAEH-QASQMLAKALT-WLGWFNSAINPFIYAFYSVDFRAAF 605
            .|..||.|:  ::|::...|.| ....:....:| ||.|.||||||.||......|:.||
 Frog   317 IFAICWAPY--SFLMSIRAACHGYCIHIYWYDITFWLLWTNSAINPIIYPLCHKGFQKAF 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	60/190 (32%)
		TM helix 1	118..144	CDD:320189	13/25 (52%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	12/29 (41%)
		TM helix 4	232..255	CDD:320189	5/22 (23%)
		TM helix 5	272..297	CDD:320189	3/24 (13%)
		7tm_GPCRs	<533..605	CDD:475119	24/73 (33%)
		TM helix 6	539..561	CDD:320189	7/21 (33%)
		TM helix 7	573..598	CDD:320189	12/25 (48%)
hrh4.b2	XP_031760447.1	7tmA_Histamine_H3R_H4R	44..374	CDD:320176	101/484 (21%)
		TM helix 2	65..92	CDD:320176	9/26 (35%)
		TM helix 3	103..133	CDD:320176	12/29 (41%)
		TM helix 4	148..166	CDD:320176	4/17 (24%)
		TM helix 5	191..221	CDD:320176	5/29 (17%)
		TM helix 6	302..332	CDD:320176	9/31 (29%)
		TM helix 7	342..367	CDD:320176	12/24 (50%)