Protein Alignment TyrR and adra2b

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_002932610.1
• Gene: adra2b / 100485811
• XenbaseID: XB-GENE-999343
• Length: 410
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 147/516 - (28%)
• Similarity: 232/516 - (44%)
• Gaps: 127/516 - (24%)

  Fly   110 LVLSWQGIILIAVFATFIVV-TVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPA 173
            |..|.|...:||...||:|: |:.||.|||:|:||:|.|:...|.|::|||.||:||...::|.:
 Frog     5 LSYSIQATAVIAAIITFLVLFTIFGNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPFS 69

  Fly   174 VAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMI 238
            :|..|:|.|..|...|:::::||||.||:||:.|||||:|||.:|::.:.|:.||..||:..| |
 Frog    70 LANELMGYWYFGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCI-I 133

  Fly   239 LIVWLLALAITCPPMLGWYEPGRRDLR---ECRYNQNEGYVIFSAMGSFFIPMAVMIYVYARISC 300
            ||||.||..|:.||::  |:...:|..   ||:.|:...|::.|::.|||.|..:||.||.|| .
 Frog   134 LIVWTLAALISLPPLI--YKGKSKDQNAKPECKLNEEPWYILSSSICSFFAPCLIMILVYLRI-Y 195

  Fly   301 VIASRHD--NMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQD 363
            :||.|.:  |.||     ||.|: .|..:.:..::...:||..|.|....|        ::|...
 Frog   196 LIAKRRNRKNSTD-----KKLKK-MAPGLFSRTNKHSLNSSHTQTQCGIIS--------SQEKTG 246

  Fly   364 MMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLK 428
            :.|.|                         .||    .:|   |..|....:||
 Frog   247 LALDD-------------------------LHC----GVP---VLSSTREERNG----------- 268

  Fly   429 RASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGERDRERLR 493
                                                  .:.|....|:..:.:|::|
 Frog   269 --------------------------------------HSESFGLQPQGENLKHTNG-------- 287

  Fly   494 SHHHHPHYHHQAGVTTTSTSGNT-----SANTNSKSLSNRITSLKKENKTTQTLSIVVGGFIACW 553
                    ...|.:.|.:|....     .|..:..|.:.:.:.:.:|.:.|..|::|:|.|:.||
 Frog   288 --------CEPAVMDTVATVKGVMLMPKGAKDSDLSSAKKKSYINREKRFTFVLAVVIGVFVLCW 344

  Fly   554 LPFFINYLITPFLAE-HQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRF 613
            .|||..|.:.....| ......:.:...|:|:.||::||.||..::.|||.||.|:.|..:
 Frog   345 FPFFFTYSLGAICTELCYIPDSVFQFFFWIGYCNSSLNPVIYTIFNQDFRKAFRRILCSHW 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	83/189 (44%)
		TM helix 1	118..144	CDD:320189	13/26 (50%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	12/22 (55%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	24/72 (33%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	8/24 (33%)
adra2b	XP_002932610.1	7tmA_alpha2B_AR	7..397	CDD:320444	142/504 (28%)
		TM helix 1	14..40	CDD:320444	13/25 (52%)
		TM helix 2	47..73	CDD:320444	11/25 (44%)
		TM helix 3	85..115	CDD:320444	17/29 (59%)
		TM helix 4	127..150	CDD:320444	13/25 (52%)
		TM helix 5	168..197	CDD:320444	12/29 (41%)
		TM helix 6	324..354	CDD:320444	12/29 (41%)
		TM helix 7	365..390	CDD:320444	8/24 (33%)