Protein Alignment TyrR and chrm2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: XP_002942846.2
• Gene: chrm2 / 100485603
• XenbaseID: XB-GENE-6034896
• Length: 470
• Species: Xenopus tropicalis
• Alignment Length: 523
• Identity: 132/523 - (25%)
• Similarity: 223/523 - (42%)
• Gaps: 104/523 - (19%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :.::.|..:..:||:|||.||:::|...|.|:|:.|.|:.|||.|||::|:|.|.......:||.
 Frog    27 VFIVIVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGY 91

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLAL 246
            |.:|.|:||:|::||.::..||:::|..||.|||..||:||||. .||:.::|.:||...|:|:.
 Frog    92 WPIGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP-VRRTTKMAGMMIAAAWVLSF 155

  Fly   247 AITCPPMLGW-YEPGRRDL--REC--RYNQNEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRH 306
            .:..|.:|.| :..|.|.:  .||  ::..|......:|:.:|::|:.:|..:|.:||....||
 Frog   156 ILWAPAILFWQFIVGGRTVPEGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWQISRASKSR- 219

  Fly   307 DNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDN 371
                     .||.|: .||..::.:|.                   ||      :|..::..::|
 Frog   220 ---------IKKGKK-EAAPNQDPISP-------------------SN------VQGKIVKPNNN 249

  Fly   372 CAAMGAGGAGGG---GGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTA 433
            ..|....|...|   .|..:|.:|..:|                        :......|..|..
 Frog   250 NVAANEDGLDHGKIQNGKVTSNSGIENC------------------------VQAEGEEKEISND 290

  Fly   434 STTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQP-PRTHSFRHSHGERDRERLRSHHH 497
            ||:::.:               .::..|....|...|.||. |:|     .:.:....|:.:...
 Frog   291 STSVSVV---------------NTKDEGAAKDVPQASGSQANPKT-----ENSKLTCIRIVTKSP 335

  Fly   498 HPHYHHQAGVTTTSTSGNTSANTNSKS--LSNRITSLKK-----------ENKTTQTLSIVVGGF 549
            .....:..|.|.....|....|...|.  ::.:|..:.|           |.|.|:|:..::..|
 Frog   336 KGDCSNATGTTVEIVPGANGRNGEDKQNIVARKIVKMTKQPPKKKLPPSREKKVTRTILAILLAF 400

  Fly   550 IACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRLTCKRFF 614
            |..|.|:.:..||..|.|....:.:..... ||.:.||.|||..||..:..|:..|..|...::.
 Frog   401 IITWTPYNVMVLINTFCAVCVPNTVWTIGY-WLCYINSTINPACYALCNTTFKKTFKHLLMCQYK 464

  Fly   615 SAG 617
            :.|
 Frog   465 NIG 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	69/190 (36%)
		TM helix 1	118..144	CDD:320189	9/25 (36%)
		TM helix 2	151..177	CDD:320189	11/25 (44%)
		TM helix 3	189..219	CDD:320189	13/29 (45%)
		TM helix 4	232..255	CDD:320189	6/22 (27%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	23/82 (28%)
		TM helix 6	539..561	CDD:320189	6/21 (29%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
chrm2	XP_002942846.2	7tmA_mAChR_M2	27..455	CDD:320424	129/509 (25%)
		TM helix 1	28..54	CDD:320424	9/25 (36%)
		TM helix 2	61..87	CDD:320424	11/25 (44%)
		TM helix 3	99..129	CDD:320424	13/29 (45%)
		TM helix 4	141..164	CDD:320424	6/22 (27%)
		TM helix 5	186..215	CDD:320424	8/28 (29%)
		TM helix 6	384..414	CDD:320424	9/29 (31%)
		TM helix 7	423..448	CDD:320424	9/25 (36%)