Protein Alignment TyrR and adrb2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001116897.2
• Gene: adrb2 / 100144654
• XenbaseID: XB-GENE-494302
• Length: 419
• Species: Xenopus tropicalis
• Alignment Length: 549
• Identity: 129/549 - (23%)
• Similarity: 189/549 - (34%)
• Gaps: 234/549 - (42%)

  Fly    83 PGPTAPVTTFNYYNESAAAAEWAHFYDLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRL 147
            |..|......|..|.|.|:.:..   |..:...|||:..:    ::|.|:||.|||.||...:||
 Frog    11 PNSTLEQLVSNVSNTSNASDKPG---DAWMVGMGIIMSCI----VLVIVLGNVLVITAIAKFQRL 68

  Fly   148 RTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTASILSLCAISV 212
            :|:||.|:.|||.||||:|:.|:|...:..::.:|......|:.|.|:|:|..||||.:||.|:|
 Frog    69 QTVTNYFITSLACADLLMGLIVVPFGASSIILDTWVFNNFWCEFWTSVDILCVTASIETLCVIAV 133

  Fly   213 DRYLAVTRPLTYSRKRRSKRLALIMILIVWLLA-LAITCPPMLGWYEPGRRDLRECRYNQ----- 271
            |||.|:|.|..| :...:|..|.|:||:||::: |....|..:.||.........| |:.
 Frog   134 DRYFAITSPFRY-QSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRIEEESALHC-YDDPSCCF 196

  Fly   272 ---NEGYVIFSAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSE 333
               |..|.|.|::.||::|:.|||:||||:.
 Frog   197 FFTNPAYAISSSIISFYLPLVVMIFVYARVF---------------------------------- 227

  Fly   334 QEQHSSVGQRQRQATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQS 398
                                 |...|:|:.:..|:.
 Frog   228 ---------------------QEAKKQLKKIDKSEG----------------------------- 242

  Fly   399 LLALPSGGVGGSMGCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQT 463
                                                                             
 Frog   243 ----------------------------------------------------------------- 242

  Fly   464 GQVQTHSLSQPPRTHSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNR 528
                                                .:|:|          |...:||.|..:.|
 Frog   243 ------------------------------------RFHNQ----------NNQQDTNGKQGNKR 261

  Fly   529 ITSL-KKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAK---------ALTWLG 583
            .:.. .||:|..:||.|::|.|..|||||||..::          |::.|         .|.|:|
 Frog   262 TSKFWLKEHKALKTLGIIMGTFTLCWLPFFIVNIV----------QVMHKDFIPVKVYNFLNWVG 316

  Fly   584 WFNSAINPFIYAFYSVDFRAAFWRLTCKR 612
            :.|||.||.||. .|.|||..|..|.|.|
 Frog   317 YVNSAFNPLIYC-RSPDFRYTFQELLCLR 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	74/194 (38%)
		TM helix 1	118..144	CDD:320189	10/25 (40%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	8/23 (35%)
		TM helix 5	272..297	CDD:320189	12/24 (50%)
		7tm_GPCRs	<533..605	CDD:475119	31/80 (39%)
		TM helix 6	539..561	CDD:320189	12/21 (57%)
		TM helix 7	573..598	CDD:320189	12/33 (36%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	118/510 (23%)
		TM helix 1	39..65	CDD:341355	12/29 (41%)
		TM helix 2	72..99	CDD:341355	13/26 (50%)
		TM helix 3	110..140	CDD:341355	17/29 (59%)
		TM helix 4	152..175	CDD:341355	8/22 (36%)
		TM helix 5	200..232	CDD:341355	15/86 (17%)
		TM helix 6	267..297	CDD:341355	15/39 (38%)
		TM helix 7	306..331	CDD:341355	10/25 (40%)