Protein Alignment TyrR and htr5aa

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001119882.2
• Gene: htr5aa / 100038775
• ZFINID: ZDB-GENE-060531-129
• Length: 345
• Species: Danio rerio
• Alignment Length: 522
• Identity: 126/522 - (24%)
• Similarity: 198/522 - (37%)
• Gaps: 192/522 - (36%)

  Fly    90 TTFNYYNESAAAAEWAHFY--DLVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITN 152
            ::||  |:|   :::.:.|  ..|.|   ::...:.|..:|.|...|.||::.||..|....:.:
Zfish     8 SSFN--NQS---SDYGNVYRPQTVFS---VLTFTLLAMLVVATFFWNMLVLVTILRVRTFHRVPH 64

  Fly   153 CFVMSLAVADLLVGIFVMPPAVAVHLIG-SWQLGWVLCDIWISLDVLLCTASILSLCAISVDRYL 216
            ..|.|:|::|::|...|||.::...|.| .|:||.|||.:|||.|||.|||||.::.||::|||.
Zfish    65 NLVASMAISDVMVAALVMPLSLVHELNGRRWKLGRVLCQVWISFDVLCCTASIWNVTAIALDRYW 129

  Fly   217 AVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAM 281
            ::||.|.|:.|.| |:::.:||.:.|||:..|:..|:.||.|....:..||:.:|...|.|||..
Zfish   130 SITRHLEYTLKTR-KKISNVMIGLTWLLSSVISLSPLFGWGETYSEENMECQVSQEPSYTIFSTF 193

  Fly   282 GSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQ 346
            |:|::|:.|:::||                       :|.|.||                 :.|.
Zfish   194 GAFYLPLCVVLFVY-----------------------WKIYKAA-----------------KFRI 218

  Fly   347 ATSRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSM 411
            .:.||
Zfish   219 GSKRT------------------------------------------------------------ 223

  Fly   412 GCAKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPR 476
                                   .|||                    |..:.|:|:..|..||..
Zfish   224 -----------------------NTIT--------------------PVAEAGEVKEASRQQPQM 245

  Fly   477 THSFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQT 541
            ..:.||:                       ..|..|...|...             :||.:....
Zfish   246 VFTVRHA-----------------------TVTFQTDSETWRE-------------QKEKRAALM 274

  Fly   542 LSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFW 606
            :.|::|.|:.||:|||:..||||..:.| ...:......|||:.||..||.||..::.::..||.
Zfish   275 VGILIGVFVLCWIPFFLTELITPLCSCH-IPPIWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAFR 338

  Fly   607 RL 608
            .|
Zfish   339 NL 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	71/186 (38%)
		TM helix 1	118..144	CDD:320189	8/25 (32%)
		TM helix 2	151..177	CDD:320189	8/25 (32%)
		TM helix 3	189..219	CDD:320189	17/29 (59%)
		TM helix 4	232..255	CDD:320189	7/22 (32%)
		TM helix 5	272..297	CDD:320189	10/24 (42%)
		7tm_GPCRs	<533..605	CDD:475119	24/71 (34%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	9/24 (38%)
htr5aa	NP_001119882.2	7tmA_5-HT5	29..337	CDD:320451	116/488 (24%)
		TM helix 1	30..56	CDD:320451	8/25 (32%)
		TM helix 2	63..89	CDD:320451	8/25 (32%)
		TM helix 3	102..132	CDD:320451	17/29 (59%)
		TM helix 4	144..165	CDD:320451	6/20 (30%)
		TM helix 5	184..213	CDD:320451	12/51 (24%)
		TM helix 6	266..296	CDD:320451	11/29 (38%)
		TM helix 7	305..330	CDD:320451	9/24 (38%)