DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Hrh3

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_598610.1 Gene:Hrh3 / 99296 MGIID:2139279 Length:445 Species:Mus musculus


Alignment Length:570 Identity:144/570 - (25%)
Similarity:219/570 - (38%) Gaps:171/570 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 DGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVI 96
            ||   |:..|.|..|:..|.|...|           .|.||...|| |:..::|:.||:||.||:
Mouse     7 DG---LMNASGALAGEAAAAGGARG-----------FSAAWTAVLA-ALMALLIVATVLGNALVM 56

  Fly    97 LAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGS 161
            ||.:....|||..|.|::||||:|:|||...:|..|...:||.|.||..||.:|:.:|.|||:.|
Mouse    57 LAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASS 121

  Fly   162 ILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV--------G 218
            :.::..||.||:|:||:.::|..::...|.|:..:.:||:.|..:..|..|.|..:        |
Mouse   122 VFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEG 186

  Fly   219 RHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDV 283
            ...|||.   ||..  :::.::...||.|...:.:..:.| |:...||.|:..|...|...:...
Mouse   187 HCYAEFF---YNWY--FLITASTLEFFTPFLSVTFFNLSI-YLNIQRRTRLRLDGGREAGPEPPP 245

  Fly   284 DGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPS--AATNAAAKGHQSSVKCSKCSKCSSA 346
            |..                 |:            |||:  :......|||..::...:.....:.
Mouse   246 DAQ-----------------PS------------PPPAPPSCWGCWPKGHGEAMPLHRYGVGEAG 281

  Fly   347 ----TGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHY 407
                ||.||.|.|:|                                    ||            
Mouse   282 PGVETGEAGLGGGSG------------------------------------GG------------ 298

  Fly   408 VGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHG 472
                |:.|.|...|:.|..|                                 ..|.:...||..
Mouse   299 ----AAASPTSSSGSSSRGT---------------------------------ERPRSLKRGSKP 326

  Fly   473 QQSHHNHHHRMPMRVSTT-------KRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPA-- 528
            ..|..:...||.| ||.:       .||.|.||:|.|::.....||.|:.:..::     |.|  
Mouse   327 SASSASLEKRMKM-VSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMII-----RAACH 385

  Fly   529 --VLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQK 575
              .:.|..:..: |:.|.|.|:||.:|...:..||.||.:|    :|.||
Mouse   386 GHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKL----LCPQK 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 68/199 (34%)
TM helix 1 78..101 CDD:410628 10/22 (45%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 7/21 (33%)
TM helix 4 194..210 CDD:410628 3/15 (20%)
TM helix 5 233..256 CDD:410628 3/22 (14%)
7tm_GPCRs <491..563 CDD:475119 22/76 (29%)
TM helix 6 497..519 CDD:320098 7/21 (33%)
TM helix 7 531..556 CDD:320098 8/25 (32%)
Hrh3NP_598610.1 7tmA_Histamine_H3R 48..423 CDD:320423 122/500 (24%)
TM helix 2 69..96 CDD:320423 12/26 (46%)
TM helix 3 107..137 CDD:320423 12/29 (41%)
TM helix 4 152..170 CDD:320423 4/17 (24%)
TM helix 5 195..225 CDD:320423 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..259 7/53 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 273..336 19/147 (13%)
TM helix 6 351..381 CDD:320423 10/34 (29%)
TM helix 7 391..416 CDD:320423 8/24 (33%)

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