Protein Alignment TyrRII and TAAR8

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_444508.1
• Gene: TAAR8 / 83551
• HGNCID: 14964
• Length: 342
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 98/487 - (20%)
• Similarity: 150/487 - (30%)
• Gaps: 219/487 - (44%)

  Fly    86 LVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIW 150
            |:.|.||.||:.:||..::|.:.||..:.:||..|:|||..||..|:|..:...|.||...|.:.
Human    43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLH 107

  Fly   151 ISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSIT-CPPYLGW 214
            ...|:..|..|:|.||.|.:|||:.||.||.|:.| .:..::.:.|.|.||..|:.: ...|.|.
Human   108 SCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATK-FTVSVSGICISVSWILPLTYSGAVFYTGV 171

  Fly   215 YEVGRHQAEFVD-------CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRD 272
            .:.|..  |.|.       |:...::|:|:...: .||||..||:.:|.||  .|.:::|.|..:
Human   172 NDDGLE--ELVSALNCVGGCQIIVSQGWVLIDFL-LFFIPTLVMIILYSKI--FLIAKQQAIKIE 231

  Fly   273 AYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKC 337
            ..|.:..          |.||.|
Human   232 TTSSKVE----------SSSESY------------------------------------------ 244

  Fly   338 SKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTP 402
                                                                             
Human   245 ----------------------------------------------------------------- 244

  Fly   403 SGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHH 467
                                                                             
Human   245 ----------------------------------------------------------------- 244

  Fly   468 HGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP--RPAVL 530
                              ::...||:.|.||||.:.:...:..|||:.|..|:..|:.  .||.:
Human   245 ------------------KIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYI 291

  Fly   531 EDLMFGFTWIGWVNCAINPFIYAFYNPDFRTA 562
            .::.   .|..:.|.|:||.|||.:.|.||.|
Human   292 YEIC---CWSAYYNSAMNPLIYALFYPWFRKA 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	65/191 (34%)
		TM helix 1	78..101	CDD:410628	7/14 (50%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	5/16 (31%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	27/74 (36%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
TAAR8	NP_444508.1	7tmA_TAAR6_8_9	32..321	CDD:320439	98/487 (20%)
		TM helix 1	33..59	CDD:320439	8/15 (53%)
		TM helix 2	66..92	CDD:320439	12/25 (48%)
		TM helix 3	104..134	CDD:320439	11/29 (38%)
		TM helix 4	146..169	CDD:320439	5/22 (23%)
		TM helix 5	193..222	CDD:320439	11/31 (35%)
		TM helix 6	250..280	CDD:320439	12/29 (41%)
		TM helix 7	289..314	CDD:320439	9/27 (33%)