Protein Alignment TyrRII and adra1aa

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001311383.1
• Gene: adra1aa / 798498
• ZFINID: ZDB-GENE-030131-2831
• Length: 485
• Species: Danio rerio
• Alignment Length: 526
• Identity: 136/526 - (25%)
• Similarity: 210/526 - (39%)
• Gaps: 195/526 - (37%)

  Fly    60 VPSMNSYLVSMAWPKSLAVAVFLVIILV-TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLV 123
            ||.:|..       |::|:.|.|.|.:| .|:||.||||:|...|.|||||:.|::|||:.|.|:
Zfish    32 VPELNVM-------KAVALGVVLAIFIVFGVLGNILVILSVACHRNLRTVTHYFIVNLAVADLLL 89

  Fly   124 GTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRS 188
            .:.|:|.|.|..:.|.|.||...||:|.::|:|.|:.||:|||.||:|||:.|:.||.|......
Zfish    90 SSTVLPFSTVFEMLGRWIFGRPFCDVWAAMDVLCCTASIMSLCVISVDRYIGVSYPLQYPSIVTE 154

  Fly   189 KRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLY 253
            :| |||.::.:|:.:::|:..|..||.|........  |:..:..||.:|||:|||::||.|:|.
Zfish   155 RR-ALLALIALWVLSITISIGPLFGWKEPAPDDESI--CKITEEPGYAIFSALGSFYLPLVVILS 216

  Fly   254 VYVKIGYVLTSRRQR-IVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHD 317
            :|.:: ||:..|..| ::....:|:              |:|
Zfish   217 MYCRV-YVVARRETRGLISGQKTEK--------------SDH----------------------- 243

  Fly   318 PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSS 382
                                                      .:|:|.:
Zfish   244 ------------------------------------------AETVTLR---------------- 250

  Fly   383 LIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEA 447
             ||                                  .||:          ||:       |.||
Zfish   251 -IH----------------------------------RGNM----------TVS-------EDEA 263

  Fly   448 KQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512
            .:                            |..| ..:|:....|:.|.||||.||:|..:.|||
Zfish   264 LR----------------------------NRTH-FALRLLKFSREKKAAKTLGIVVGCFVLCWL 299

  Fly   513 PFFVYYLLIPFLP--RPAVLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQ 574
            |||:...:....|  ||:   |.:|..| |:|:.|..|||.||...:.:|:.||..:......::
Zfish   300 PFFLVLPIGSIFPTYRPS---DTVFKITFWLGYFNSCINPIIYPCSSQEFKKAFLSVLGARCLRK 361

  Fly   575 KRPPNH 580
            :..|:|
Zfish   362 RSTPSH 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	80/193 (41%)
		TM helix 1	78..101	CDD:410628	12/23 (52%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	12/22 (55%)
		7tm_GPCRs	<491..563	CDD:475119	30/74 (41%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	11/25 (44%)
adra1aa	NP_001311383.1	7tm_GPCRs	41..350	CDD:475119	128/491 (26%)
		TM helix 1	43..67	CDD:410628	12/23 (52%)
		TM helix 2	76..98	CDD:410628	8/21 (38%)
		TM helix 3	114..136	CDD:410628	11/21 (52%)
		TM helix 4	159..175	CDD:410628	3/15 (20%)
		TM helix 5	196..219	CDD:410628	12/22 (55%)
		TM helix 6	284..306	CDD:410628	13/21 (62%)
		TM helix 7	318..343	CDD:410628	11/24 (46%)