Protein Alignment TyrRII and chrm1a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_073777932.1
• Gene: chrm1a / 792708
• ZFINID: ZDB-GENE-090410-9
• Length: 465
• Species: Danio rerio
• Alignment Length: 537
• Identity: 125/537 - (23%)
• Similarity: 211/537 - (39%)
• Gaps: 134/537 - (24%)

  Fly    70 MAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVL 134
            ::|..::...:.:.:.|:|:.||.||:::......||||:|.|:::||:.|.::|:..|......
Zfish    18 ISWKTAMITFITVPLSLITITGNVLVMISFRVNPLLRTVSNYFLLSLAVADVILGSISMNLYTTY 82

  Fly   135 YITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVV 199
            .:...|..|.:.||:|:::|.:..:.|:::|.|||:||||:|.:||||..||..|| |::||.:.
Zfish    83 ILLNGWTLGNLACDVWLAVDYVASNASVMNLLAISIDRYLSVMRPLTYRAKRTPKR-AMIMISLA 146

  Fly   200 WITALSITCPPYLGW-YEVGRHQAEFVDCRYN-QNKGYVVF-SAMGSFFIPLTVMLYVYVKIGYV 261
            |..:..|..|..|.| |.||....:..:|... .::..:.| :|:.:|::|::||:.:|.::...
Zfish   147 WTISFVIWAPAILFWQYIVGERTVQENECSIQFLSEPVITFGTAIAAFYLPVSVMVALYWRVYRE 211

  Fly   262 LTSRRQRIV---------------RDAYSERTADYDVDGDNFISESE-----------HYHCTPT 300
            ...|.|::.               |...|...::.||.......:.:           ..|.|..
Zfish   212 TEKRSQKLAGLMASQGGRTGNASQRSCQSSSRSNEDVRPQTDQQQQQLRNEPRPVCPSFTHRTAA 276

  Fly   301 KWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTF 365
            .|   :|.|.|    .|...|.|||...:....|.:....:|.....|          :||:...
Zfish   277 CW---KKQRER----EDISNSYATNNHPQVDFISSRTDHNNKYIPLVG----------MDKSAAN 324

  Fly   366 K-HQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTT 429
            | |..|.                                         :.||.....|...|..|
Zfish   325 KPHDATM-----------------------------------------NNSDQSESPNSLMNPAT 348

  Fly   430 TTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDS 494
            |..:.:.|..                                ||:|.       ..|.|:..::.
Zfish   349 TQASALLLNA--------------------------------GQRSR-------KARTSSLIKEK 374

  Fly   495 KTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDL-MFGFTWIGWVNCAINPFIYAFYNPD 558
            |.|:||:.::...|..|.|:.:..|:..|... .|.|.| ..|: |:.:||..:||..||..|..
Zfish   375 KAARTLSAILLAFIVTWTPYNIMVLVSTFCDN-CVPERLWKLGY-WLCYVNSTVNPLCYALCNKH 437

  Fly   559 FRTAFWRLTCRPICKQK 575
            ||..|..|.   :|:.|
Zfish   438 FRVTFRALL---LCRWK 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	62/194 (32%)
		TM helix 1	78..101	CDD:410628	6/22 (27%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	6/23 (26%)
		7tm_GPCRs	<491..563	CDD:475119	23/72 (32%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	10/25 (40%)
chrm1a	XP_073777932.1	None