Protein Alignment TyrRII and drd1a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_021336831.1
• Gene: drd1a / 792634
• ZFINID: ZDB-GENE-130522-1
• Length: 363
• Species: Danio rerio
• Alignment Length: 508
• Identity: 129/508 - (25%)
• Similarity: 192/508 - (37%)
• Gaps: 209/508 - (41%)

  Fly    83 VIILVTVVGNTLVILAVLTTRRLRT-VTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWIL 146
            ::||.|::|||||..||...|.||: |||.||::||::|.||...|||...|..:.|.|.|| ..
Zfish    33 LLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAILVMPWKAVTEVAGFWPFG-AF 96

  Fly   147 CDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSIT-CPP 210
            ||||::.||:..:.|||:||.||:|||.|::.|..|.:| .:.|:|.:||.|.|..::.|: .|.
Zfish    97 CDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERK-MTPRVAFVMISVAWTLSVLISFIPV 160

  Fly   211 YLGWYEV---------GRHQAEFVD-CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSR 265
            .|.|::.         ..|:|...| |..:.|:.|.:.|::.||:||:.:|:..|.:|..:...:
Zfish   161 QLKWHKAQPTSFPEANASHRALLTDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQ 225

  Fly   266 RQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKG 330
            .:||   :..||.|:                        :.|.|      ||...|::.
Zfish   226 IRRI---SALERAAE------------------------SAKIR------HDSMGSSSN------ 251

  Fly   331 HQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGG 395
                                                                             
Zfish   252 ----------------------------------------------------------------- 251

  Fly   396 PCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDH 460
                        |.:|:||                                        :.||
Zfish   252 ------------VDSESSF----------------------------------------KLSF-- 262

  Fly   461 HHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP 525
                                          ||::|..|||:::||..:.||||||:...::||..
Zfish   263 ------------------------------KRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCK 297

  Fly   526 R-----PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF-WRLTCRPIC 572
            |     |.:.......|.|.||.|.::||.|||| |.|||.|| ..|.|:.:|
Zfish   298 RTSVGLPCISPTTFDVFVWFGWANSSLNPIIYAF-NADFRRAFAILLGCQRLC 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	76/198 (38%)
		TM helix 1	78..101	CDD:410628	10/17 (59%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	5/16 (31%)
		TM helix 5	233..256	CDD:410628	7/22 (32%)
		7tm_GPCRs	<491..563	CDD:475119	33/76 (43%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	11/24 (46%)
drd1a	XP_021336831.1	7tm_GPCRs	24..339	CDD:475119	124/496 (25%)
		TM helix 1	27..51	CDD:410628	10/17 (59%)
		TM helix 2	61..83	CDD:410628	11/21 (52%)
		TM helix 3	98..120	CDD:410628	11/21 (52%)
		TM helix 4	143..159	CDD:410628	5/15 (33%)
		TM helix 5	193..216	CDD:410628	7/22 (32%)
		TM helix 6	269..291	CDD:410628	11/21 (52%)
		TM helix 7	308..333	CDD:410628	11/25 (44%)