Protein Alignment TyrRII and adrb3b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_073770286.1
• Gene: adrb3b / 792519
• ZFINID: ZDB-GENE-081022-154
• Length: 415
• Species: Danio rerio
• Alignment Length: 528
• Identity: 119/528 - (22%)
• Similarity: 198/528 - (37%)
• Gaps: 215/528 - (40%)

  Fly    74 KSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITG 138
            |.|.|....::|.:||:||.|||||:..|..|.|.||.|::::|..|.::|..|.|..:.:.:.|
Zfish    14 KPLLVLPLALVIFLTVIGNLLVILAIARTPLLHTTTNVFIISMAFADLIMGCVVQPLGLSMVVAG 78

  Fly   139 TWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITA 203
            .|..|..:||:|.|||:...:.||.:||||:::||:|:|:||.: :....||.|..::..|||.:
Zfish    79 KWVLGNPMCDLWTSLDVFCVTASIETLCAIAVERYIAITRPLEH-QVLLGKRRAAYIVCTVWIVS 142

  Fly   204 LSITCPPYLGWYEVGRHQAEFVD----------CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKI 258
            ..::..|.:.    ...:|.::.          |.::.|:.|.:||::.||::||.||:::|.|:
Zfish   143 SLVSFVPIMN----HNSRANYLAANDCYNNSECCDFHTNQHYAIFSSVVSFYVPLLVMVFLYGKV 203

  Fly   259 GYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAA 323
             :.:.:::.:::                                   .|.|.||
Zfish   204 -FAIANKQLKLI-----------------------------------GKDRLRF----------- 221

  Fly   324 TNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSA 388
                                                                    |||   |:.
Zfish   222 --------------------------------------------------------LSS---CNE 227

  Fly   389 ISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQ 453
            .||:        .|.     |:..|:|            ..||.:.|
Zfish   228 DSCE--------IPE-----GSARSYS------------RRTTKHVV------------------ 249

  Fly   454 QRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYY 518
                                                  ::.|..|||.|:||....||||||::.
Zfish   250 --------------------------------------KEHKALKTLGIIMGIFSLCWLPFFIFN 276

  Fly   519 LLIPFLPR-PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPPN--- 579
            ::..|.|. |..|..|:  ..|:|:.|..:||.||. ::|::|.||:.|..   ||:.:..|
Zfish   277 IIKSFNPEVPTQLVFLL--LNWLGYANSGLNPIIYC-HSPEYRNAFFNLLG---CKKPKHFNQTT 335

  Fly   580 ---HLAMF 584
               ||..|
Zfish   336 VNKHLQSF 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	64/201 (32%)
		TM helix 1	78..101	CDD:410628	11/22 (50%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	27/72 (38%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
adrb3b	XP_073770286.1	None