Protein Alignment TyrRII and hrh2a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 512
• Identity: 121/512 - (23%)
• Similarity: 180/512 - (35%)
• Gaps: 235/512 - (45%)

  Fly    76 LAVAVFL-VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGT 139
            :|:||.| |:||:||.||.||.|||..|||||.|||||:::||:||:|:|..|:|.|.:..:||.
Zfish     5 IALAVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQVTGD 69

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |..|...|:|:||||::||:.|||:|.|||||||.|||.||.|.......|:..: :..:|:.::
Zfish    70 WPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAI-LATIWLVSV 133

  Fly   205 SIT-CPPYLGW---------YEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIG 259
            .:: .|.:|||         ...|.|..   |||:..|..|.:..|..:|::||..|.:.|.::.
Zfish   134 GVSFVPIHLGWNTRDLSVQNIREGDHAR---DCRFELNPTYAIVDAFSTFYLPLLAMCWSYHRVF 195

  Fly   260 YVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAAT 324
            .:...|.:||:
Zfish   196 RIARMRAKRII------------------------------------------------------ 206

  Fly   325 NAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAI 389
             :..:|..||                     .||...||
Zfish   207 -STRRGSTSS---------------------QGVTILTL-------------------------- 223

  Fly   390 SCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQ 454
                                                                             
Zfish   224 ----------------------------------------------------------------- 223

  Fly   455 RSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYL 519
                                                 |:.|...||.:|:|..:.||.|:|.::.
Zfish   224 -------------------------------------REHKATVTLAVVLGAFVVCWFPYFTFFT 251

  Fly   520 LI--------PFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            ::        |...:..||        |:|:.|.|:||.:||..|.|||:|:.:|.|
Zfish   252 IMGIRNEENPPQTAQSVVL--------WLGYANSALNPVLYATLNRDFRSAYAKLLC 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	84/202 (42%)
		TM helix 1	78..101	CDD:410628	15/23 (65%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	1/16 (6%)
		TM helix 5	233..256	CDD:410628	6/22 (27%)
		7tm_GPCRs	<491..563	CDD:475119	25/79 (32%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	118/505 (23%)
		TM helix 1	6..32	CDD:320179	16/25 (64%)
		TM helix 2	39..66	CDD:320179	13/26 (50%)
		TM helix 3	77..107	CDD:320179	20/29 (69%)
		TM helix 4	119..139	CDD:320179	2/20 (10%)
		TM helix 5	168..198	CDD:320179	8/29 (28%)
		TM helix 6	223..253	CDD:320179	11/157 (7%)
		TM helix 7	263..288	CDD:320179	10/32 (31%)