Protein Alignment TyrRII and Gpr84

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001102979.1
• Gene: Gpr84 / 688730
• RGDID: 1585277
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 547
• Identity: 114/547 - (20%)
• Similarity: 181/547 - (33%)
• Gaps: 183/547 - (33%)

  Fly    62 SMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTC 126
            :.:.|..|:...:..||...:|:.....|||.|.:||:....:|||..|..:.||.:.|.|..|.
  Rat     8 NFSCYHESVLGYRYFAVIWGMVVAATGTVGNVLTLLALAIRPKLRTRFNLLIANLTLADLLYCTL 72

  Fly   127 VMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRL 191
            :.|.||..|:...||.|.|.|.|:..|.....|.|||:||.|:|.|||.:..|..:.:...:|.:
  Rat    73 LQPFSVDTYLHLHWRTGAIFCRIFGLLLFTSNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGI 137

  Fly   192 ALLMI--LVVWITALS----------ITCPPYLGWYEVGRHQAEFVDCRYNQNKG--YVVFSAMG 242
            .|.::  .||.:|:.:          :.|                 .|.:::.:|  |... .||
  Rat   138 VLALVGSWVVGVTSFAPLWNVYVLVPVVC-----------------TCSFDRVRGRPYTTI-LMG 184

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRR-QRIVR--DAYSERTA---DYDVDGDNFISESEHYHCTPTK 301
            .||    |:....|.:.|.|..|: :|..|  |.|..:.|   .:.|.|
  Rat   185 IFF----VVGLSSVGVFYCLIHRQVKRAARALDKYGLQEASMRSHQVSG---------------- 229

  Fly   302 WLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFK 366
                                  |:.|..||...:.          :|.|..|...|:
  Rat   230 ----------------------THEAVPGHFQELD----------SGLASRGPSEGI-------- 254

  Fly   367 HQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTT 431
                                                                    .|...:..|
  Rat   255 --------------------------------------------------------SSEPVSAAT 263

  Fly   432 TNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKT 496
            |.|:..:::|..: :..:|..||.|.......|....|:.|.:             ..|...|:.
  Rat   264 TQTLEGDSSEAGD-QGMRKAAQQISERSLPEVHRKTGGAAGAR-------------RATDAPSEF 314

  Fly   497 AKTLTIVMGGLIACWLPFFVYYLLIPFLP----RPAVLEDLMFGFTWIGWVNCAINPFIYAFYNP 557
            .| :|.:...:..|::..::.:||:..|.    .|.|:..:....||:   |..|||.:||..|.
  Rat   315 GK-VTRMCFAVFLCFVLSYIPFLLLNILDARGRAPRVVHMVAANLTWL---NSCINPVLYAAMNR 375

  Fly   558 DFRTAFWRLTCRPICKQKRPPNHLAMF 584
            .||.|:..:.       ||.|.....|
  Rat   376 QFRQAYGSIL-------KRGPQSFRRF 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	59/206 (29%)
		TM helix 1	78..101	CDD:410628	8/22 (36%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	4/27 (15%)
		TM helix 5	233..256	CDD:410628	7/24 (29%)
		7tm_GPCRs	<491..563	CDD:475119	20/75 (27%)
		TM helix 6	497..519	CDD:320098	3/21 (14%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Gpr84	NP_001102979.1	7tmA_GPR84-like	21..381	CDD:320338	107/511 (21%)
		TM helix 1	22..48	CDD:320338	9/25 (36%)
		TM helix 2	55..78	CDD:320338	7/22 (32%)
		TM helix 3	93..123	CDD:320338	14/29 (48%)
		TM helix 4	137..155	CDD:320338	4/17 (24%)
		TM helix 5	175..200	CDD:320338	9/29 (31%)
		TM helix 6	312..342	CDD:320338	6/30 (20%)
		TM helix 7	349..374	CDD:320338	9/27 (33%)