Protein Alignment TyrRII and Htr1f

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_068629.2
• Gene: Htr1f / 60448
• RGDID: 71083
• Length: 366
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 130/506 - (25%)
• Similarity: 199/506 - (39%)
• Gaps: 170/506 - (33%)

  Fly    73 PKSLAVAVFLV-IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            |..:.|::.|. :.|:|...|:|||.|::.||:|....|..:.:||:||:||...|||.|:|..:
  Rat    21 PSKILVSLTLSGLALMTTTINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIV 85

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            :.:|..|..|||:|:|:||:.||.|||.|.||:||||.|:|..:.|::| |:.|.|.:.|..||:
  Rat    86 SESWIMGQGLCDLWLSVDIICCSCSILHLSAIALDRYRAITDAVEYARK-RTPRHAGITITTVWV 149

  Fly   202 TALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVV---FSAMGSFFIPLTVMLYVYVKIGYVLT 263
            .::.|:.|| |.|    |||....|.:......::|   :|..|:|:|||.::|.:|.||
  Rat   150 ISVFISMPP-LFW----RHQGNSRDDQCIIKHDHIVSTIYSTFGAFYIPLVLILILYYKI----- 204

  Fly   264 SRRQRIVRDAYSERTAD----YDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAAT 324
               .|..|..|.:|.|.    .:::|...:...|
  Rat   205 ---YRAARTLYHKRQASRMIKEELNGQVLLESGE------------------------------- 235

  Fly   325 NAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAI 389
                    .|:|                                     ||..|.:
  Rat   236 --------KSIK-------------------------------------LVSTSYM--------- 246

  Fly   390 SCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQ 454
                                .|.|.||
  Rat   247 --------------------LEKSLSD-------------------------------------- 253

  Fly   455 RSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYL 519
             .|.|....|:.......:..|.....|  .::|.| |:.|.|.||.:::|..:.|||||||..|
  Rat   254 -PSTDFDRIHSTVKSPRSELKHEKSWRR--QKISGT-RERKAATTLGLILGAFVICWLPFFVKEL 314

  Fly   520 LIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLT-CR 569
            ::....:..:.|::.....|:|::|..|||.||..:|.||:.||.:|. ||
  Rat   315 VVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	76/195 (39%)
		TM helix 1	78..101	CDD:410628	9/23 (39%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	8/25 (32%)
		7tm_GPCRs	<491..563	CDD:475119	26/71 (37%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	9/24 (38%)
Htr1f	NP_068629.2	7tmA_5-HT1F	24..359	CDD:320456	125/495 (25%)
		TM helix 1	25..51	CDD:320456	9/25 (36%)
		TM helix 2	58..84	CDD:320456	12/25 (48%)
		TM helix 3	96..126	CDD:320456	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	8/22 (36%)
		TM helix 5	178..207	CDD:320456	11/36 (31%)
		TM helix 6	286..316	CDD:320456	15/30 (50%)
		TM helix 7	326..351	CDD:320456	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)