DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TyrRII and PTGER4

DIOPT Version :9

Sequence 1:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_000949.1	Gene:	PTGER4 / 5734	HGNCID:	9596	Length:	488	Species:	Homo sapiens

Alignment Length:	291	Identity:	75/291 - (25%)
Similarity:	128/291 - (43%)	Gaps:	61/291 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LGVPSMNSYLVSMAWPKSL--AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCF--VMNLAI 118
            :..|.:|| ..|:: |..|  .|.:..|:.:..||||.:.|:.:..:|:.:..|..:  |..||:
Human     1 MSTPGVNS-SASLS-PDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAV 63

  Fly   119 TDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILS-LCAISLDRYLAVTQPLTY 182
            ||.|....|.|.::..|:.|.|..|..||: :.:..:|..|.|.|| :||:|::||||:.....|
Human    64 TDLLGTLLVSPVTIATYMKGQWPGGQPLCE-YSTFILLFFSLSGLSIICAMSVERYLAINHAYFY 127

  Fly   183 SKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAE------FVDCRYN--QNKGY-VVF 238
            | ....||||.|.:..|:.:.:.....|.:|   :|..:.:      |:|...|  .:..| .::
Human   128 S-HYVDKRLAGLTLFAVYASNVLFCALPNMG---LGSSRLQYPDTWCFIDWTTNVTAHAAYSYMY 188

  Fly   239 SAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWL 303
            :...||.|..||:..|.| .|.:|...||      :..||:         :...:|:
Human   189 AGFSSFLILATVLCNVLV-CGALLRMHRQ------FMRRTS---------LGTEQHH-------- 229

  Fly   304 PNRKSRWRFNSLHDPPPSAATNAAAKGHQSS 334
                            .:||.:.|::||.::
Human   230 ----------------AAAAASVASRGHPAA 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	43/132 (33%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	57/197 (29%)
PTGER4	NP_000949.1	7tmA_PGE2_EP4	18..341	CDD:320270	69/272 (25%)
		TM helix 1	19..45	CDD:320270	7/25 (28%)
		TM helix 2	54..80	CDD:320270	8/25 (32%)
		TM helix 3	92..122	CDD:320270	13/30 (43%)
		TM helix 4	134..156	CDD:320270	6/21 (29%)
		TM helix 5	180..209	CDD:320270	8/29 (28%)
		TM helix 6	265..295	CDD:320270
		TM helix 7	308..333	CDD:320270
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7791
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860