Protein Alignment TyrRII and htr6

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_009295353.2
• Gene: htr6 / 568269
• ZFINID: ZDB-GENE-030131-7839
• Length: 540
• Species: Danio rerio
• Alignment Length: 561
• Identity: 129/561 - (22%)
• Similarity: 188/561 - (33%)
• Gaps: 226/561 - (40%)

  Fly    64 NSYLVSMAW------PKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWL 122
            :|..:|..|      |..|||.:.| |||||..||.|:|..|...|.||..:|||:::|.::|.:
Zfish    94 DSSTISDGWSIGGSGPWLLAVMLSL-IILVTACGNILLIALVFAHRSLRCTSNCFLVSLFLSDLM 157

  Fly   123 VGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRR 187
            |...||||:::..:.|||......|.:|:..|::.||.|||:||.|||||||.:..||.| |:..
Zfish   158 VALVVMPPAMLNVLCGTWVLAPGFCPVWLCFDVMCCSASILNLCVISLDRYLLIISPLRY-KQHM 221

  Fly   188 SKRLALLMILVVW-ITALSITCPPYLGWYEVGRHQAEFVD------------------------- 226
            :...|||::...| :.||:...|..:.|:.:||.|....|
Zfish   222 TPPRALLLVGGAWGLAALTSFLPIKMDWHSLGRMQELTEDDPGNATHLNSFYPSSYFQLSSSGMP 286

  Fly   227 ---CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQ-----RIVRDAYSERTADYDV 283
               ||......:.:.:...:||:|.|.:.:.|.:|  :|.:|||     .:...||.:
Zfish   287 STQCRLRVTLPFALVATFLTFFLPSTAICFTYCRI--LLAARRQARQVEALTHPAYPQ------- 342

  Fly   284 DGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDP--PPSAATNAAAKGHQSSVKCSKCSKCSSA 346
                                         :||.:|  |||       .||
Zfish   343 -----------------------------HSLGEPSRPPS-------PGH--------------- 356

  Fly   347 TGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTE 411
                                                     ||
Zfish   357 -----------------------------------------AI---------------------- 358

  Fly   412 ASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSH 476
                                                     |....:.|..|....|......|.
Zfish   359 -----------------------------------------QDGDDYSHQEPPGLRHAPLSVNSE 382

  Fly   477 HNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGF---- 537
            ....||.      .||..|.:.||.:::|...:.|||||:..:      ..||.|.:...|
Zfish   383 RRLAHRQ------RKRALKASLTLGVLLGLFFSAWLPFFITNM------AQAVCECVPPSFFDAI 435

  Fly   538 TWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPP 578
            ||:|:.|..:||.||..:..||:.|..||.  |.|...:.|
Zfish   436 TWLGYCNSTMNPIIYPMFMRDFKRALARLL--PCCSSSQAP 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	73/225 (32%)
		TM helix 1	78..101	CDD:410628	12/22 (55%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/16 (25%)
		TM helix 5	233..256	CDD:410628	4/22 (18%)
		7tm_GPCRs	<491..563	CDD:475119	25/75 (33%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	10/28 (36%)
htr6	XP_009295353.2	None