Protein Alignment TyrRII and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 856
• Identity: 183/856 - (21%)
• Similarity: 274/856 - (32%)
• Gaps: 384/856 - (44%)

  Fly    51 TGAGAGKLGVPSM---------NSYLVSMAWPKSLAVAVFLVIILV--TVVGNTLVILAVLTTRR 104
            |||.|| ||...:         :|..:...|       ..|.||||  |..||.||.||::..||
Mosquito    88 TGAEAG-LGPDRIDADDDEDDGSSLALHNYW-------ALLAIILVFGTAAGNILVCLAIVWERR 144

  Fly   105 LRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAIS 169
            |:.|||.|:|:|||||.:|...|||..::..:.|.:......|.:||.||:|.|:.||:.||.||
Mosquito   145 LQNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYCLVWICLDVLFCTASIMHLCTIS 209

  Fly   170 LDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVD--CRYNQN 232
            :||||::..|:.:. :.:::|..:|.|..||:.:::::.|..|.:.:  .|.:..||  |:...
Mosquito   210 VDRYLSLRYPMKFG-RNKTRRRVVLKISFVWLLSIAMSLPLSLMYSK--NHASVLVDGTCQIPD- 270

  Fly   233 KGYVVFSAMGS---FFIPLTVMLYVYVKIGYVLTSRR---------------------------- 266
               .|:..:||   |:|||.|||     |.|.||.|.
Mosquito   271 ---PVYKLVGSIVCFYIPLCVML-----ITYTLTVRLLAQQSENLGGVGSGGGWSSGWLGQAPAF 327

  Fly   267 ------QRIVR---------DAYSERTADYDV--------------------------------- 283
                  :||::         .|:|..:.|.::
Mosquito   328 DRRNTWKRIIKLSLPAAQNPHAHSAASTDTELSTLDNHDLWLLESSIPEPSSITMTAMQRFGEEM 392

  Fly   284 -----------------DGDNFIS-------ESEHYHCTP------------------------- 299
                             .|.|..|       |.|.:...|
Mosquito   393 LKLSQGLESVAQHSDRNSGQNGSSRSPEPSREKESFRKKPANAKHAPTPVTMVTVRSPVPSKKRR 457

  Fly   300 ---TKWLPNRKS---------RWRFNSL-HDPPPSAATNAAA-----------------KG--HQ 332
               :.|:..|.|         |.||.|| |..||.|:.:...                 :|  |.
Mosquito   458 SSTSTWIARRNSGTPPPVRLVRKRFKSLPHALPPPASDDIEVDEQFMQDVLYELRDREDRGSVHG 522

  Fly   333 SSVKCSKC------SKCSSATGTAGAGAGAGVVDKTLTFKHQPT----FYELVEVSRLSSLIHCS 387
            ||.:....      :..|.||.....|..||         ..|.    .:.|...|:       :
Mosquito   523 SSARPGAAGLDGVPAAASRATSDRREGRDAG---------SNPAGPRQAHPLAAPSQ-------T 571

  Fly   388 AISCKYGGPC-------------MHSTPSGMHYVGTEASFSDTCLGGNVSN-------------- 425
            |.:.|...||             .:..|:.:..|.|...|..  :||..||
Mosquito   572 AATLKLPPPCKCPFFGEGAPGRQQYLRPAEIKIVKTSTDFGP--MGGAASNGDSLVYSTISISSG 634

  Fly   426 -NTTTTTTNTV--ALETNEKLEAEA--------------------KQKQQQQRSSF--------- 458
             |.||..|.::  :|.|   |.|.|                    :::.|::.|||
Mosquito   635 SNVTTQPTRSISSSLST---LPASALASPSRKGSAPKGISVVTWDQRRHQRRGSSFGGARTSLLL 696

  Fly   459 ---------------------------------------------DHHHPHAHHH---------- 468
                                                         :...|....|
Mosquito   697 TPTKASPSSVSLRRSINLRHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQTGGGGGGGA 761

  Fly   469 --GSHGQ------------------------QSHHNHHHRMPMRVST-----TKRDSKTAKTLTI 502
              |.:|.                        :|||:.:..|..|.|:     .:.:.|..|.|.:
Mosquito   762 VGGGNGTAVAMMAVAAASSTVPTLATTTMAVRSHHSRNSSMISRNSSRHGRIIRLEQKATKVLGV 826

  Fly   503 VMGGLIACWLPFFVYYLLIPFLPRPAV-------LEDLMFGF-TWIGWVNCAINPFIYAFYNPDF 559
            |....:..|.||||..||      |:|       ::..:|.| ||:|:.:..:||..|..:|..|
Mosquito   827 VFFTFVILWAPFFVLNLL------PSVCKHCEDNIDQWVFEFVTWLGYASSLVNPIFYTIFNKAF 885

  Fly   560 RTAFWR-LTCR 569
            |.||.: |.||
Mosquito   886 RDAFRKVLLCR 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	75/232 (32%)
		TM helix 1	78..101	CDD:410628	12/24 (50%)
		TM helix 2	110..132	CDD:410628	12/21 (57%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	10/25 (40%)
		7tm_GPCRs	<491..563	CDD:475119	24/79 (30%)
		TM helix 6	497..519	CDD:320098	8/21 (38%)
		TM helix 7	531..556	CDD:320098	8/25 (32%)
5-HT2B	XP_061501050.1	None