Protein Alignment TyrRII and adrb2a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001096122.1
• Gene: adrb2a / 565838
• ZFINID: ZDB-GENE-100414-3
• Length: 405
• Species: Danio rerio
• Alignment Length: 511
• Identity: 119/511 - (23%)
• Similarity: 179/511 - (35%)
• Gaps: 217/511 - (42%)

  Fly    83 VIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILC 147
            :::|:.|.||.:||.|:...:||:.|||||:.:||..|.::|..|:|...:..|..||.||..||
Zfish    37 ILVLIIVFGNVMVITAISRFQRLQNVTNCFITSLACADLVMGLVVIPFGALYIILNTWHFGHFLC 101

  Fly   148 DIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITA-LSITCPPY 211
            |.|.:.|:|..:.||.:||.|::|||:|:|.|..| :...:|..|..::|:||:.| |....|.:
Zfish   102 DFWTATDVLCVTASIETLCVIAMDRYIAITSPFRY-QSLLTKNRARFIVLMVWVIAGLVSYLPIH 165

  Fly   212 LGWYEVGRHQA-----EFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVR 271
            :.|:....::.     ....|.::....|.:.|::.||:|||.:|::||           .|:.:
Zfish   166 MEWWISTDNETLCCYNNTYCCEFDITYSYAIVSSIISFYIPLVIMVFVY-----------SRVFQ 219

  Fly   272 DAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVK 336
            :|                                ||...:.|.
Zfish   220 EA--------------------------------RKQLKKINK---------------------- 230

  Fly   337 CSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHST 401
                                                                             
Zfish   231 ----------------------------------------------------------------- 230

  Fly   402 PSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAH 466
                    ||..|                                                 ||.
Zfish   231 --------TEGRF-------------------------------------------------HAQ 238

  Fly   467 HHGSHGQQSHHNHHHRMPMRVSTTK-----RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR 526
            ...|..|...:||..   || ||.|     ::.|..|||.|:||....|||||||    :..:|:
Zfish   239 KSNSRNQDVANNHSE---MR-STKKAKFYLKEHKALKTLGIIMGVFTLCWLPFFV----LNVIPK 295

  Fly   527 PAVLEDLMFGF---TWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPPN 579
            .:|  |: :.|   .|||:.|.|.||.||. .:||||.||..:.|   ..:.|.||
Zfish   296 GSV--DI-WTFRILNWIGYANSAFNPLIYC-GSPDFRYAFKEILC---LNRSRYPN 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	64/192 (33%)
		TM helix 1	78..101	CDD:410628	7/17 (41%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	5/16 (31%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	32/79 (41%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	11/27 (41%)
adrb2a	NP_001096122.1	7tm_GPCRs	31..331	CDD:475119	113/493 (23%)
		TM helix 1	31..55	CDD:410628	7/17 (41%)
		TM helix 2	64..86	CDD:410628	9/21 (43%)
		TM helix 3	102..124	CDD:410628	9/21 (43%)
		TM helix 4	147..163	CDD:410628	5/15 (33%)
		TM helix 5	192..215	CDD:410628	10/33 (30%)
		TM helix 6	270..291	CDD:410628	13/24 (54%)
		TM helix 7	300..325	CDD:410628	10/26 (38%)