DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRII and adra1ab

DIOPT Version :9

Sequence 1:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_021334987.1	Gene:	adra1ab / 557259	ZFINID:	ZDB-GENE-060503-384	Length:	431	Species:	Danio rerio

Alignment Length:	494	Identity:	129/494 - (26%)
Similarity:	194/494 - (39%)	Gaps:	183/494 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KSLAVAVFLVIILV-TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |:|.:.:.||:.|: .|:||.||||:|...|.||:||:.|:.||||.|.|:.:.|:|.|.|....
Zfish    35 KTLVLGLVLVLFLIFGVMGNILVILSVACHRNLRSVTHYFIGNLAIADLLLSSVVLPFSAVSEAL 99

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWIT 202
            |.|.||..||:.|.:||:|.|:.||||||.||:||.:||:.||.|......:| |:..:..:|..
Zfish   100 GRWVFGRHLCNAWTALDVLCCTASILSLCVISVDRCMAVSYPLQYPSFATGRR-AMTAVAALWAL 163

  Fly   203 ALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQ 267
            :.:|:..|..||.| ...:.|.| ||.|::.||.:|||..||::||.|:|.:|.:: ||:...:
Zfish   164 SAAISVGPLFGWRE-PMPEDESV-CRVNEDPGYAIFSAACSFYVPLAVILAMYCRV-YVVARHK- 224

  Fly   268 RIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQ 332
                                                                    |.|.:|..:
Zfish   225 --------------------------------------------------------TRAMSKSRE 233

  Fly   333 SSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPC 397
            ::                      |:.::.:|.:                 |||.
Zfish   234 TN----------------------GLSEQGMTLR-----------------IHCR---------- 249

  Fly   398 MHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHH 462
                                    ...|:|                     :|:...|..
Zfish   250 ------------------------KAQNDT---------------------RKEDAMRLK----- 264

  Fly   463 PHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP-- 525
                           |.|... ||:....|:.|.||||.||:|..:.||||||:...:....|
Zfish   265 ---------------NSHFAF-MRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVLPISSIFPSH 313

  Fly   526 RPAVLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAF 563
            ||   .|.:|..| |:|:.|..:||.||..::.:|:.||
Zfish   314 RP---PDAVFKITFWLGYFNSCLNPIIYPCFSQEFKKAF 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	58/130 (45%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	76/185 (41%)
adra1ab	XP_021334987.1	7tm_GPCRs	48..349	CDD:333717	122/479 (25%)
		TM helix 2	72..94	CDD:320095	9/21 (43%)
		TM helix 3	110..132	CDD:320095	12/21 (57%)
		TM helix 4	155..171	CDD:320095	2/15 (13%)
		TM helix 5	192..215	CDD:320095	11/22 (50%)
		TM helix 6	280..305	CDD:320095	14/24 (58%)
		TM helix 7	317..342	CDD:320095	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010