Protein Alignment TyrRII and adra1ab

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_021334987.2
• Gene: adra1ab / 557259
• ZFINID: ZDB-GENE-060503-384
• Length: 431
• Species: Danio rerio
• Alignment Length: 494
• Identity: 129/494 - (26%)
• Similarity: 194/494 - (39%)
• Gaps: 183/494 - (37%)

  Fly    74 KSLAVAVFLVIILV-TVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |:|.:.:.||:.|: .|:||.||||:|...|.||:||:.|:.||||.|.|:.:.|:|.|.|....
Zfish    35 KTLVLGLVLVLFLIFGVMGNILVILSVACHRNLRSVTHYFIGNLAIADLLLSSVVLPFSAVSEAL 99

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWIT 202
            |.|.||..||:.|.:||:|.|:.||||||.||:||.:||:.||.|......:| |:..:..:|..
Zfish   100 GRWVFGRHLCNAWTALDVLCCTASILSLCVISVDRCMAVSYPLQYPSFATGRR-AMTAVAALWAL 163

  Fly   203 ALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQ 267
            :.:|:..|..||.| ...:.|.| ||.|::.||.:|||..||::||.|:|.:|.:: ||:...:
Zfish   164 SAAISVGPLFGWRE-PMPEDESV-CRVNEDPGYAIFSAACSFYVPLAVILAMYCRV-YVVARHK- 224

  Fly   268 RIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQ 332
                                                                    |.|.:|..:
Zfish   225 --------------------------------------------------------TRAMSKSRE 233

  Fly   333 SSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPC 397
            ::                      |:.::.:|.:                 |||.
Zfish   234 TN----------------------GLSEQGMTLR-----------------IHCR---------- 249

  Fly   398 MHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHH 462
                                    ...|:|                     :|:...|..
Zfish   250 ------------------------KAQNDT---------------------RKEDAMRLK----- 264

  Fly   463 PHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP-- 525
                           |.|... ||:....|:.|.||||.||:|..:.||||||:...:....|
Zfish   265 ---------------NSHFAF-MRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVLPISSIFPSH 313

  Fly   526 RPAVLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAF 563
            ||   .|.:|..| |:|:.|..:||.||..::.:|:.||
Zfish   314 RP---PDAVFKITFWLGYFNSCLNPIIYPCFSQEFKKAF 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	80/192 (42%)
		TM helix 1	78..101	CDD:410628	11/23 (48%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	12/21 (57%)
		TM helix 4	194..210	CDD:410628	2/15 (13%)
		TM helix 5	233..256	CDD:410628	11/22 (50%)
		7tm_GPCRs	<491..563	CDD:475119	29/74 (39%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	10/25 (40%)
adra1ab	XP_021334987.2	None