Protein Alignment TyrRII and chrm5a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001018639.1
• Gene: chrm5a / 553978
• ZFINID: ZDB-GENE-080723-32
• Length: 490
• Species: Danio rerio
• Alignment Length: 524
• Identity: 124/524 - (23%)
• Similarity: 208/524 - (39%)
• Gaps: 108/524 - (20%)

  Fly    72 WPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            |.......|..::..:|::||.||:|:.....:|:||.|.::::||..|.::|...|.......:
Zfish    23 WEVIAIATVSAIVSFITIIGNILVMLSFKVNSQLKTVNNYYLLSLAFADLIIGVFSMNLYTSYIL 87

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            .|.|..|.:.||:|::||.:..:.|:::|..||.|||.::|:||||..||..| :|.:||.:.|:
Zfish    88 MGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPK-IAGIMIGLAWL 151

  Fly   202 TALSITCPPYLGW-YEVGRHQAEFVDCRYN-QNKGYVVF-SAMGSFFIPLTVMLYVYVKIGYVLT 263
            .:..:..||.|.| |.||:.......|:.. .::..:.| :|:.:|:.|::||..:|..| |..|
Zfish   152 VSFILWAPPILCWQYFVGKRTVPERQCQIQFFSEPVITFGTAIAAFYFPVSVMTILYCLI-YKET 215

  Fly   264 SRRQRIVRDAYSERTADY-DVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAA 327
            .|           ||.|. ::.|.|                                  ::||::
Zfish   216 ER-----------RTKDLAELQGIN----------------------------------SSTNSS 235

  Fly   328 AKGHQSSVKCSKCSKCSSATGTAGAGA-----GAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCS 387
              |.....|...|..|...:.|:...|     .|..:|..||  :..::....|..|
Zfish   236 --GDAQPQKIRSCFGCKHVSNTSRTQALSHTNAAKTLDDQLT--NFNSYASSEEEDR-------- 288

  Fly   388 AISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQ 452
              |..:...|.|.......|  .|.:|..|.:     ..:.|.|...|:.:...|..:..|....
Zfish   289 --SGNFQESCRHQENKSESY--EEENFFPTPV-----KASPTKTKKCVSYKFKPKDVSPLKNTNG 344

  Fly   453 QQR---SSFDHHHPHAHHHGSHGQQSHHNHHHRMP----MRVSTTKR-------DSKTAKTLTIV 503
            ..:   |||.         .:....:..:.....|    ::...|||       :.|.|:||:.:
Zfish   345 DAKPGASSFS---------SAESVNAPSSSSSSKPIDGTLKCQITKRKRMVLIKEKKAAQTLSAI 400

  Fly   504 MGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF----- 563
            :...|..|.|:.:..|:..|......|.....|: |:.:||..:||..||..|..|:..|
Zfish   401 LLAFILTWTPYNIMVLISTFCSDCIPLSLWHLGY-WLCYVNSTVNPMCYALCNKTFQKTFRMLLL 464

  Fly   564 --WR 565
              ||
Zfish   465 CQWR 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	62/194 (32%)
		TM helix 1	78..101	CDD:410628	7/22 (32%)
		TM helix 2	110..132	CDD:410628	6/21 (29%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	6/23 (26%)
		7tm_GPCRs	<491..563	CDD:475119	22/78 (28%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
chrm5a	NP_001018639.1	7tmA_mAChR_M5	26..459	CDD:320427	120/510 (24%)
		TM helix 1	27..53	CDD:320427	7/25 (28%)
		TM helix 2	60..86	CDD:320427	6/25 (24%)
		TM helix 3	98..128	CDD:320427	12/29 (41%)
		TM helix 4	140..163	CDD:320427	7/23 (30%)
		TM helix 5	185..214	CDD:320427	9/29 (31%)
		TM helix 6	388..418	CDD:320427	8/29 (28%)
		TM helix 7	427..452	CDD:320427	9/25 (36%)