DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and drd4-rs

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_001012638.3 Gene:drd4-rs / 503566 ZFINID:ZDB-GENE-051113-172 Length:418 Species:Danio rerio


Alignment Length:511 Identity:137/511 - (26%)
Similarity:215/511 - (42%) Gaps:133/511 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 LAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVL-YITGT 139
            ||:...:.:||:.::||.||.|:|||.|.|:|.||.|:::||:.|.|:...|:|..|.. ::.|.
Zfish    20 LALICGVPLILIIILGNVLVCLSVLTERSLKTATNYFIVSLAVADLLLAILVLPLYVYSEFLGGI 84

  Fly   140 WRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITAL 204
            |.....:||..:::|::||:.|||:|||||:|||:||..||.|::.:.|.| .|.:|...|:.:|
Zfish    85 WTLSMYICDALMTMDVMLCTASILNLCAISVDRYIAVVVPLKYNRNQFSVR-QLALITATWVLSL 148

  Fly   205 SITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRI 269
            .:..|...|..:|.......  |:...|: :||:|::.|||:|..|||::|.             
Zfish   149 GVASPVIFGLNQVPNRNPHV--CKLEDNQ-FVVYSSVCSFFVPCPVMLFLYY------------- 197

  Fly   270 VRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRW----RFNSLHDPPPSAATNAAAKG 330
                                            |:.....||    ..:.|..||         :|
Zfish   198 --------------------------------WMFRGLKRWSSGRNRSHLRRPP---------RG 221

  Fly   331 HQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGG 395
            .:|         .|...|.|        :.|              |..|....:           
Zfish   222 RRS---------LSLRLGAA--------LQK--------------EKGRAREKV----------- 244

  Fly   396 PCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLE-----AEAKQKQQQQR 455
              ::..|:|:         |.|.|  ..:..|..::|:.|.|.|::..|     ||:.....|..
Zfish   245 --VYLMPAGL---------SPTSL--TATPTTPISSTSPVTLTTDDLAEGQMPGAESDPMTTQMD 296

  Fly   456 SSFDHHHPHAHHHGSHGQQS--------HHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512
            |..|..:|........|:::        |....|....|||  .|:.|..|.|.:|:|..:|||.
Zfish   297 SVSDAENPERATEDDSGRENGVGKNHRPHTGRRHSKSNRVS--GRERKAMKVLPVVVGVFLACWT 359

  Fly   513 PFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            ||||.::.........:...|:...||:|:||.|:||.||..:|.:||..|.:|.|
Zfish   360 PFFVVHVTKALCESCDIGPTLISVVTWLGYVNSAVNPIIYTAFNVEFRNVFHKLLC 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 68/192 (35%)
TM helix 1 78..101 CDD:410628 8/22 (36%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 11/21 (52%)
TM helix 4 194..210 CDD:410628 3/15 (20%)
TM helix 5 233..256 CDD:410628 10/22 (45%)
7tm_GPCRs <491..563 CDD:475119 27/71 (38%)
TM helix 6 497..519 CDD:320098 11/21 (52%)
TM helix 7 531..556 CDD:320098 11/24 (46%)
drd4-rsNP_001012638.3 7tmA_D4_dopamine_R 19..410 CDD:320434 134/504 (27%)
TM helix 1 20..46 CDD:320434 11/25 (44%)
TM helix 2 53..79 CDD:320434 10/25 (40%)
TM helix 3 92..122 CDD:320434 17/29 (59%)
TM helix 4 134..157 CDD:320434 6/23 (26%)
TM helix 5 173..202 CDD:320434 13/74 (18%)
TM helix 6 338..368 CDD:320434 13/29 (45%)
TM helix 7 378..403 CDD:320434 11/24 (46%)

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