Protein Alignment TyrRII and drd4b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 523
• Identity: 129/523 - (24%)
• Similarity: 206/523 - (39%)
• Gaps: 162/523 - (30%)

  Fly    61 PSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGT 125
            |::.:|.|.       |:...:::|:|.:.||.||.|:|...:.|:|.||.|:::||:.|.::..
Zfish    11 PALFTYNVP-------ALVFGILLIIVIICGNVLVCLSVYKEKALKTTTNYFIVSLAVADLMLAV 68

  Fly   126 CVMPPSVVL-YITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSK 189
            .|:|..|.. :..|.|.....:||..:::|::||:.||.:|||||:||::||:.||.|::|....
Zfish    69 LVLPLFVYAEFQGGVWSLNVSVCDGLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRKHVDY 133

  Fly   190 RLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYV 254
            | .::::...|:.||::..|...|...|  .|.:..:|:...| .|||:|::.|||||..:||.:
Zfish   134 R-QIILLSATWLLALAVASPVIFGINNV--PQRDPSECKLEDN-NYVVYSSVCSFFIPCPIMLML 194

  Fly   255 YVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPP 319
            |..:.:.|                                     .||...||::.| ||:
Zfish   195 YFGMFHGL-------------------------------------RKWEETRKAKLR-NSI---- 217

  Fly   320 PSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGA----GA------GVVDKTLTFKHQPTFYEL 374
                                 ..|.|....|.|.|    ||      .|:::.|.
Zfish   218 ---------------------QACRSLQHAAVAAALPPLGALPASLPRVIERDLA---------- 251

  Fly   375 VEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALET 439
              .|.|..|...:...|.:.....:||      :.|.| :||...|
Zfish   252 --QSSLEELDDFTQPVCPFPPEYKNST------IQTVA-YSDIQYG------------------- 288

  Fly   440 NEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVM 504
                     ||.|:::                              |.....|:.|..:.|.:|:
Zfish   289 ---------QKTQRKK------------------------------RAKINGRERKAMRVLPVVV 314

  Fly   505 GGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCR 569
            |..:.||.||||.:..........:..|||...||:|:||.|:||.||..:|.:||..|.....|
Zfish   315 GVFLFCWTPFFVVHTTRALCESCHISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFFRGFVPR 379

  Fly   570 PIC 572
            ..|
Zfish   380 CCC 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	64/192 (33%)
		TM helix 1	78..101	CDD:410628	8/22 (36%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	11/22 (50%)
		7tm_GPCRs	<491..563	CDD:475119	27/71 (38%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	13/24 (54%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	123/496 (25%)
		TM helix 1	20..45	CDD:320434	9/24 (38%)
		TM helix 2	52..78	CDD:320434	9/25 (36%)
		TM helix 3	91..121	CDD:320434	15/29 (52%)
		TM helix 4	133..156	CDD:320434	5/23 (22%)
		TM helix 5	172..201	CDD:320434	13/29 (45%)
		TM helix 6	301..331	CDD:320434	11/29 (38%)
		TM helix 7	341..366	CDD:320434	13/24 (54%)