Protein Alignment TyrRII and drd4a

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001012634.2
• Gene: drd4a / 503564
• ZFINID: ZDB-GENE-070112-996
• Length: 380
• Species: Danio rerio
• Alignment Length: 542
• Identity: 123/542 - (22%)
• Similarity: 203/542 - (37%)
• Gaps: 199/542 - (36%)

  Fly    67 LVSMAWPKSLAVA-----------VF-LVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAIT 119
            :|....|.:|.::           :| :::|::.:.||.||.|:|.|.:.|:|.||.|:::||:.
Zfish     1 MVEADMPANLTISTHTTNYNFPALIFGILLIIIIICGNVLVCLSVYTEKALKTTTNYFIVSLAVA 65

  Fly   120 DWLVGTCVMPPSVVL-YITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYS 183
            |.|:...|:|..|.. :..|.|.....:||..:::|::||:.||.:|||||:||::||:.||.|:
Zfish    66 DLLLAVLVLPLFVYAEFQDGVWSLNMTVCDGLMTMDVMLCTASIFNLCAISIDRFIAVSIPLNYN 130

  Fly   184 KKRRSKRLALLMILVVWITALSITCPPYLGWYEV-GRHQAEFVDCRYNQNKGYVVFSAMGSFFIP 247
            :|...:| .::::...||.||::..|...|...| .|..:|   |:...| .||::|::.|||:|
Zfish   131 RKHVDQR-QIVLLSATWILALAVASPVMFGINNVPNRDHSE---CKLEDN-NYVIYSSVCSFFVP 190

  Fly   248 LTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRF 312
            ..:||.:|..:...|.:                                     |...||::.|.
Zfish   191 CPIMLLLYCGMFRGLRN-------------------------------------WEEARKAKLRS 218

  Fly   313 NSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAG-----AGVVDKTLTFKHQPTFY 372
            |                       ...|.|...|..:....:|     ..|::|.:|.
Zfish   219 N-----------------------MEACRKLQEAAASLQPLSGLPPPLPPVIEKDITL------- 253

  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437
                                                                             
Zfish   254 ----------------------------------------------------------------- 253

  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPH----------AHHHGSHGQQSHHNHHHRMPMRVSTTKR 492
               |:|:.:              |:|.          |:..|.:.|..:.|   |...|.....|
Zfish   254 ---EELDQD--------------HYPDPDSPDPVSMLAYPGGGYNQDQNQN---RQRKRAKINGR 298

  Fly   493 DSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG------FTWIGWVNCAINPFI 551
            :.|..:.|.:|:|..:.||.||||.:.:      .|:.||....      .||:|:||.||||.|
Zfish   299 ERKAMRVLPVVVGAFLFCWTPFFVVHTM------RALCEDCEIPGSVTSIVTWLGYVNSAINPII 357

  Fly   552 YAFYNPDFRTAFWR-LTCRPIC 572
            |..:|.:||..|.: |...|.|
Zfish   358 YTVFNTEFRKFFRKFLPTLPGC 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	66/205 (32%)
		TM helix 1	78..101	CDD:410628	8/34 (24%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	28/77 (36%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	13/30 (43%)
drd4a	NP_001012634.2	7tmA_D4_dopamine_R	36..369	CDD:320434	114/495 (23%)
		TM helix 2	55..81	CDD:320434	10/25 (40%)
		TM helix 3	94..124	CDD:320434	15/29 (52%)
		TM helix 4	136..159	CDD:320434	6/23 (26%)
		TM helix 5	175..204	CDD:320434	11/29 (38%)
		TM helix 6	297..327	CDD:320434	11/35 (31%)
		TM helix 7	337..362	CDD:320434	11/24 (46%)