Protein Alignment TyrRII and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Alignment Length: 712
• Identity: 171/712 - (24%)
• Similarity: 273/712 - (38%)
• Gaps: 196/712 - (27%)

  Fly     7 PDAMLPYSKLLST----ALTVASGNSNSSDGTLLL--------IQTSAAPGGDVMATGAGAGKLG 59
            ||.......|||.    .|...||..|.:|....|        :|.:|.......|:||.:|.|.
  Fly    29 PDNATLNPPLLSVDGQLTLPPGSGYVNVNDTIFFLNGSFYNSSLQLAAGFYNQSSASGATSGNLT 93

  Fly    60 VPSMNSYLVSMAWPKS-------LAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLA 117
            .|:.........:|..       :|..:..:::::.||||.|||:|:.|.:.|:.:.|.|:.:||
  Fly    94 NPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLA 158

  Fly   118 ITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTY 182
            :.|:.:|..:||.|:...:.|.|.||...|||..::|:|||:.||::||.||||||.::|:.:.|
  Fly   159 VADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDY 223

  Fly   183 SKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIP 247
            .|.|...| |.:||..|||.:..|..||.||| :|...:.....|..:::.|||::||:|||:||
  Fly   224 LKSRTPAR-AAVMITAVWIMSALICIPPLLGW-KVKMPEGPLPKCELSEDIGYVLYSALGSFYIP 286

  Fly   248 LTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRF 312
            ..:|::||::|.:...:|.:|.:: .:..:|.:..|                |.:...:|..
  Fly   287 SCIMVFVYIRIYFAAKARARRGIK-KHPRKTNNEQV----------------TSFTTAKKGT--- 331

  Fly   313 NSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSAT----------------GTAGAGAGAGVVDK 361
                .|.||::..:|.:.||.....:..:..:||:                .|:.||....|..:
  Fly   332 ----IPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQ 392

  Fly   362 TLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDT--------- 417
            |:.....|.......|         :.:|...|||.....|........:.|...|
  Fly   393 TVLAYANPNGAGTNSV---------TVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPV 448

  Fly   418 --CLGGNVSNNTTTTTTNTVALE------------------------------------------ 438
              .:|.|.|.|.......|||::
  Fly   449 PPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSV 513

  Fly   439 ------------------------------------------TNEKLEAEAKQKQQQQRSSFDHH 461
                                                      :|::...|||...:.|:||
  Fly   514 GVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSS---- 574

  Fly   462 HPHAHHHGSHGQQSHHNHHHRMPM---------------------RVSTTKRDSKTAKTLTIVMG 505
                 ...|..||.......:..:                     |....|::.:....|.::||
  Fly   575 -----GVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMG 634

  Fly   506 GLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            ..||||||||..|:|:|.......:.:..|... |:|::|.|:||.||..:|.|||.||.|:
  Fly   635 SFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRI 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	75/191 (39%)
		TM helix 1	78..101	CDD:410628	8/22 (36%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	12/22 (55%)
		7tm_GPCRs	<491..563	CDD:475119	28/72 (39%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	9/25 (36%)
Octalpha2R	NP_001262715.1	7tmA_alpha2_AR	132..>307	CDD:320187	72/176 (41%)
		TM helix 2	150..176	CDD:320187	9/25 (36%)
		TM helix 3	188..218	CDD:320187	17/29 (59%)
		TM helix 4	230..253	CDD:320187	10/23 (43%)
		TM helix 5	271..300	CDD:320187	14/28 (50%)
		7tm_GPCRs	<616..693	CDD:475119	28/76 (37%)
		TM helix 6	626..648	CDD:410628	11/21 (52%)
		TM helix 7	661..686	CDD:410628	9/24 (38%)