DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TyrRII and mAChR-A

DIOPT Version :9

Sequence 1:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_523844.2	Gene:	mAChR-A / 37892	FlyBaseID:	FBgn0000037	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	183/810 - (22%)
Similarity:	291/810 - (35%)	Gaps:	269/810 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAALEHPDAMLPYSKLLSTALTVASGNSNSSDGTLLLIQTSAAPGG----------------DVM 49
            :||...|..:.|..|.::|:.|..:..:.|:      ..|:|:|.|                ::.
  Fly     9 LAAHGPPSILEPLFKTVTTSTTTTTTTTTST------TTTTASPAGYSPGYPGTTLLTALFENLT 67

  Fly    50 ATGAG------AGKLGVPSMNSYLVSMAWPK----SLAVAVFLVIIL--VTVVGNTLVILAVLTT 102
            :|.|.      :|..|..:..:.......|:    |:.|..|:..||  |||.||.:|:::....
  Fly    68 STAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVTVAGNVMVMISFKID 132

  Fly   103 RRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCA 167
            ::|:|::|.|:.:|||.|:.:|...||...|..|.|.|..|.|:||.|::||.|..:.|:|:|..
  Fly   133 KQLQTISNYFLFSLAIADFAIGAISMPLFAVTTILGYWPLGPIVCDTWLALDYLASNASVLNLLI 197

  Fly   168 ISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYL-GW-YEVGRHQAEFVDC--R 228
            ||.|||.:||:||||..||.:.| |.:||...|..:| :..||:: .| |..|:......:|  :
  Fly   198 ISFDRYFSVTRPLTYRAKRTTNR-AAVMIGAAWGISL-LLWPPWIYSWPYIEGKRTVPKDECYIQ 260

  Fly   229 YNQNKGYVVF-SAMGSFFIPLTVMLYVYVKIGYVLTSRRQR-----------------------I 269
            :.:...|:.| :|:.:|:.|:|:|.::|.:| :..|.:||:                       :
  Fly   261 FIETNQYITFGTALAAFYFPVTIMCFLYWRI-WRETKKRQKDLPNLQAGKKDSSKRSNSSDENTV 324

  Fly   270 VRDAYSERTA-------DYDV-------------------------------------------- 283
            |..|.....|       |:|.
  Fly   325 VNHASGGLLAFAQVGGNDHDTWRRPRSESSPDAESVYMTNMVIDSGYHGMHSRKSSIKSTNTIKK 389

  Fly   284 ---------------------DGDNFISESEH----YHCTP-TKWLPNRKSRWRFNSLH------ 316
                                 |.|:|..|.|.    .:.|| |...|.:.|..|..|::
  Fly   390 SYTCFGSIKEWCIAWWHSGREDSDDFAYEQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNY 454

  Fly   317 -------------------DPPP---------------SAAT-------NAAAKGHQSSVKCSKC 340
                               .|.|               ||.|       |.:..|:.:....:..
  Fly   455 SMGGSVSGVRPPSILLSDVSPTPLPRPPLASISQLQEMSAVTASTTANVNTSGNGNGAINNNNNA 519

  Fly   341 S-KCSSATGTAGAGAGAGV-VDKTLTFKHQPTFYELVEVSRLSS-----------LIH-----CS 387
            | ..:.|....|||.|:|: :..|....|:.: ..|..::|::|           ||.     .|
  Fly   520 SHNGNGAVNGNGAGNGSGIGLGTTGNATHRDS-RTLPVINRINSRSVSQDSVYTILIRLPSDGAS 583

  Fly   388 AISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGG------NVSNNTTTTTTNTVALETNEKLEAE 446
            :.:...||        |....|..||.|.:..|.      .:..:..|||.....|.:     |.
  Fly   584 SNAANGGG--------GGPGAGAAASASLSMQGDCAPSIKMIHEDGPTTTAAAAPLAS-----AA 635

  Fly   447 AKQKQQQQRSS-----FDHHHPHAHHH--------------------------GSHGQQSHHNHH 480
            |.::....|.|     ......||.|.                          |:|...:..|..
  Fly   636 ATRRPLPSRDSEFSLPLGRRMSHAQHDARLLNAKVIPKQLGKAGGGAAGGGVGGAHALMNARNAA 700

  Fly   481 HRMPMRVSTTKR-DSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLP----RPAVLEDLMFGFTWI 540
            .:  .:.|..|| :||.||||:.::...|..|.|:.:..|:.|...    .|..|.|..:...:|
  Fly   701 KK--KKKSQEKRQESKAAKTLSAILLSFIITWTPYNILVLIKPLTTCSDCIPTELWDFFYALCYI 763

  Fly   541 GWVNCAINPFIYAFYNPDFRTAFWR-LTCR 569
               |..|||..||..|..||..:.| |||:
  Fly   764 ---NSTINPMCYALCNATFRRTYVRILTCK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	55/131 (42%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	68/213 (32%)
mAChR-A	NP_523844.2	7tm_4	117..>241	CDD:304433	53/125 (42%)
mAChR-A	NP_523844.2	7tm_1	121..>314	CDD:278431	66/195 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840