Protein Alignment TyrRII and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 720
• Identity: 183/720 - (25%)
• Similarity: 276/720 - (38%)
• Gaps: 208/720 - (28%)

  Fly    18 STALTVASGNSNSSD-----GTLLLIQTSAAPG------GDVMATGAGA-----GKLGVPSMNSY 66
            |.||.:...::|.::     |.:||..|....|      |:::|..:|.     |..|:....|.
  Fly   150 SPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSK 214

  Fly    67 LVSMAWPKSLAVAVFLVI----ILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCV 127
            :....:.:.|.:||..|:    ||||::||..||.|::..|.|:.|.|..|.:||:.|..|...|
  Fly   215 VAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLV 279

  Fly   128 MPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLA 192
            ||...|..|:..|..|..|||||.|.|:|.|:.|||.|.||::|||.|||. :.|...|.|.|:
  Fly   280 MPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNRV- 342

  Fly   193 LLMILVVWITALSITCPPYLGWYEVGRHQ-AEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYV 256
            .:||..||..|:.::..|..||.:....| .|...|..:|:..|.||:...:|::||.|:|.:|.
  Fly   343 FMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYW 407

  Fly   257 KIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPS 321
            ||   ..:.|:||.|    .|....|...:|                            :.|...
  Fly   408 KI---YQTARKRIHR----RRPRPVDAAVNN----------------------------NQPDGG 437

  Fly   322 AATNAAAKGHQSSVKCSKCSKCSSATGT-------AGAGAGAGVVDKTLTFKHQPTFYELVEVS- 378
            |||:  .|.|:..::..:.|...|.||:       |..|...|:||...|  :.....|..|.|
  Fly   438 AATD--TKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNST--NTVNTVEDTEFSS 498

  Fly   379 -------------------RLSSLIHCSAISCKYG------------------------------ 394
                               :::::.|..|::.:.|
  Fly   499 SNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGE 563

  Fly   395 --------------GPCMHSTPSGMHYVGTEASFSDTCL-------------------------- 419
                          ||...:..|.|...||..| .|.|.
  Fly   564 QEDREELEDQDEQVGPQPTTATSAMTAAGTNES-EDQCKANGVEVLEDPQLQQQLEQVQQLQKSV 627

  Fly   420 ----GGNVSNNTTTTTTNTVALE----TNEKL-------------------------------EA 445
                ||..|.:..||.|:..||.    |::.:                               |:
  Fly   628 KSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANES 692

  Fly   446 EAKQKQQQQRSSFDHHHPHAHHHGSHGQQ----SHHNHHHRMPMRVST--TKRDSKTAKTLTIVM 504
            .:..:.:.::.:.....||...|....||    |..|...::..|..|  .||:.|.||||.|:.
  Fly   693 PSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQKVNKRKETLEAKRERKAAKTLAIIT 757

  Fly   505 GGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC- 568
            |..:.|||||||..|.:|......:.:.:...|.|:|:.|..:||.||..::|:||.||.|:..
  Fly   758 GAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFG 822

  Fly   569 --RPI 571
              ||:
  Fly   823 GHRPV 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	78/196 (40%)
		TM helix 1	78..101	CDD:410628	12/26 (46%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	5/15 (33%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	29/71 (41%)
		TM helix 6	497..519	CDD:320098	13/21 (62%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	76/190 (40%)
		TM helix 1	228..254	CDD:320454	11/25 (44%)
		TM helix 2	261..287	CDD:320454	10/25 (40%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	7/22 (32%)
		TM helix 5	383..412	CDD:320454	11/31 (35%)
		7tm_GPCRs	<743..816	CDD:475119	29/72 (40%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	8/24 (33%)