Protein Alignment TyrRII and HTR7

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 136/538 - (25%)
• Similarity: 204/538 - (37%)
• Gaps: 206/538 - (38%)

  Fly    38 IQTSAAPGGDVMATGA-GAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLT 101
            :..|.||..|.....| |.|:    .:|...|.    |.:..::..:|.|:|:.||.||:::|..
Human    52 VTASPAPTWDAPPDNASGCGE----QINYGRVE----KVVIGSILTLITLLTIAGNCLVVISVCF 108

  Fly   102 TRRLRTVTNCFVMNLAITDWLVGTCVMP-PSVVLYITGTWRFGWILCDIWISLDILLCSGSILSL 165
            .::||..:|..:::||:.|..|...||| .||...|.|.|.||...|:::|::|::.|:.||::|
Human   109 VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTL 173

  Fly   166 CAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVD---- 226
            |.||:||||.:|:||||..::..|.:| .|||.||:.:.|||.||..||       |:.|:
Human   174 CVISIDRYLGITRPLTYPVRQNGKCMA-KMILSVWLLSASITLPPLFGW-------AQNVNDDKV 230

  Fly   227 CRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISE 291
            |..:|:.||.::|...:|:||::|||::|.:|
Human   231 CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI--------------------------------- 262

  Fly   292 SEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGA 356
               |                         .||..:|||
Human   263 ---Y-------------------------KAARKSAAK--------------------------- 272

  Fly   357 GVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGG 421
                                                      |..| |...|..:
Human   273 ------------------------------------------HKFP-GFPRVEPD---------- 284

  Fly   422 NVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMR 486
                       :.:||....||:.|.::.....|..                     .|.|  ..
Human   285 -----------SVIALNGIVKLQKEVEECANLSRLL---------------------KHER--KN 315

  Fly   487 VSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR------PAVLEDLMFGFTWIGWVNC 545
            :|..||:.|.|.||.|::|....||||||:.....||:..      |..:|..   |.|:|:.|.
Human   316 ISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERT---FLWLGYANS 377

  Fly   546 AINPFIYAFYNPDFRTAF 563
            .||||||||:|.|.||.:
Human   378 LINPFIYAFFNRDLRTTY 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	73/196 (37%)
		TM helix 1	78..101	CDD:410628	8/22 (36%)
		TM helix 2	110..132	CDD:410628	8/22 (36%)
		TM helix 3	148..170	CDD:410628	8/21 (38%)
		TM helix 4	194..210	CDD:410628	8/15 (53%)
		TM helix 5	233..256	CDD:410628	9/22 (41%)
		7tm_GPCRs	<491..563	CDD:475119	34/77 (44%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	13/24 (54%)
HTR7	NP_062873.1	7tmA_5-HT7	97..395	CDD:320452	123/483 (25%)
		TM helix 2	116..142	CDD:320452	10/25 (40%)
		TM helix 3	155..185	CDD:320452	14/29 (48%)
		TM helix 4	197..219	CDD:320452	12/22 (55%)
		TM helix 5	236..265	CDD:320452	12/89 (13%)
		TM helix 6	320..350	CDD:320452	14/29 (48%)
		TM helix 7	363..388	CDD:320452	13/27 (48%)