Protein Alignment TyrRII and HTR4

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001035263.1
• Gene: HTR4 / 3360
• HGNCID: 5299
• Length: 428
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 115/518 - (22%)
• Similarity: 175/518 - (33%)
• Gaps: 212/518 - (40%)

  Fly    74 KSLAVAVFL-VIILVTVVGNTLVILAVLTTRRLRTV-TNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            :.:.:..|| .:||:.::||.||::||...|:||.: ||.|:::||..|.||...|||...:..:
Human    18 EKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELV 82

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAV-TQPLTYSKKRRSKRLALLMILVVW 200
            ...|.:|.:.|.:..|||:||.:.||..||.||||||.|: .|||.|..|....|:| ||:...|
Human    83 QDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA-LMLGGCW 146

  Fly   201 ITALSITCPPYL-GWYEVG----------RHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYV 254
            :....|:..|.: ||..:|          ...:....|.:..||.|.:..::.:|:||..:|:..
Human   147 VIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLA 211

  Fly   255 YVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPP 319
            |.:|                             :::..||.|
Human   212 YYRI-----------------------------YVTAKEHAH----------------------- 224

  Fly   320 PSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLI 384
                                                                             
Human   225 ----------------------------------------------------------------- 224

  Fly   385 HCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQ 449
                                                                            |
Human   225 ----------------------------------------------------------------Q 225

  Fly   450 KQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPF 514
            .|..||:.....        |..|.:..:..|||       :.::|.||||.|:||....||.||
Human   226 IQMLQRAGASSE--------SRPQSADQHSTHRM-------RTETKAAKTLCIIMGCFCLCWAPF 275

  Fly   515 FVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRP 577
            ||..::.||:.. .|...:...|.|:|::|..:|||:|||.|..||.||..:.|....:.:||
Human   276 FVTNIVDPFIDY-TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	54/132 (41%)
		7tm_1	91..>277	CDD:278431	64/198 (32%)
HTR4	NP_001035263.1	7tm_1	36..312	CDD:278431	100/473 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910