Protein Alignment TyrRII and HTR1F

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000857.1
• Gene: HTR1F / 3355
• HGNCID: 5292
• Length: 366
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 133/505 - (26%)
• Similarity: 204/505 - (40%)
• Gaps: 168/505 - (33%)

  Fly    73 PKSLAVAVFLV-IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            |..:.|::.|. :.|:|...|:|||.|::.||:|....|..:.:||:||:||...|||.|:|..:
Human    21 PSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIV 85

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            ..:|..|.::||||:|:||..|:.|||.|.||:||||.|:|..:.|::||..|. |.:||.:|||
Human    86 RESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH-AGIMITIVWI 149

  Fly   202 TALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVV---FSAMGSFFIPLTVMLYVYVKI---GY 260
            .::.|:.|| |.|    |||....|........::|   :|..|:|:|||.::|.:|.||   ..
Human   150 ISVFISMPP-LFW----RHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAK 209

  Fly   261 VLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATN 325
            .|..:||       :.|.|..:|:|...:...|
Human   210 TLYHKRQ-------ASRIAKEEVNGQVLLESGE-------------------------------- 235

  Fly   326 AAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAIS 390
                         |.:|..|                        |.|.|
Human   236 -------------KSTKSVS------------------------TSYVL---------------- 247

  Fly   391 CKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQR 455
                                |.|.||.....:..::|.            ..|.:|.|.::..:|
Human   248 --------------------EKSLSDPSTDFDKIHSTV------------RSLRSEFKHEKSWRR 280

  Fly   456 SSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL 520
                                         .::|.| |:.|.|.||.:::|..:.|||||||..|:
Human   281 -----------------------------QKISGT-RERKAATTLGLILGAFVICWLPFFVKELV 315

  Fly   521 IPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLT-CR 569
            :....:..:.|::.....|:|::|..|||.||..:|.||:.||.:|. ||
Human   316 VNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	79/198 (40%)
		TM helix 1	78..101	CDD:410628	9/23 (39%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	13/21 (62%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	8/25 (32%)
		7tm_GPCRs	<491..563	CDD:475119	26/71 (37%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	9/24 (38%)
HTR1F	NP_000857.1	7tmA_5-HT1F	24..359	CDD:320456	128/494 (26%)
		TM helix 1	25..51	CDD:320456	9/25 (36%)
		TM helix 2	58..84	CDD:320456	12/25 (48%)
		TM helix 3	96..126	CDD:320456	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	10/23 (43%)
		TM helix 5	178..207	CDD:320456	11/28 (39%)
		TM helix 6	286..316	CDD:320456	15/30 (50%)
		TM helix 7	326..351	CDD:320456	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)