DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TyrRII and HTR1B

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000854.1 Gene:HTR1B / 3351 HGNCID:5287 Length:390 Species:Homo sapiens


Alignment Length:520 Identity:142/520 - (27%)
Similarity:203/520 - (39%) Gaps:179/520 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 PSMN----SYL----VSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLA 117
            ||.|    .|:    :|:.| |.|.|.:..:|.|.|.:.|..||..|..||:|.|..|..:.:||
Human    29 PSQNCSAKDYIYQDSISLPW-KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLA 92

  Fly   118 ITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTY 182
            :||.||...|||.|.:..:||.|..|.::||.|:|.||..|:.|||.||.|:||||.|:|..:.|
Human    93 VTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEY 157

  Fly   183 SKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK-GYVVFSAMGSFFI 246
            |.||..|| |.:||.:||:.::||:.||:. |.: .:.:.|..:|..|.:. .|.|:|.:|:|:.
Human   158 SAKRTPKR-AAVMIALVWVFSISISLPPFF-WRQ-AKAEEEVSECVVNTDHILYTVYSTVGAFYF 219

  Fly   247 PLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNR--KSR 309
            |..:::.:|   |.:....|.||:                              |..|||  |..
Human   220 PTLLLIALY---GRIYVEARSRIL------------------------------KQTPNRTGKRL 251

  Fly   310 WRFNSLHDPPPSAATNAAAKGHQSSVKC--SKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
            .|...:.|.|          |..|||..  |:.....|.:|:                   |.:.
Human   252 TRAQLITDSP----------GSTSSVTSINSRVPDVPSESGS-------------------PVYV 287

  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437
            ..|:| |:|.                                                     ||
Human   288 NQVKV-RVSD-----------------------------------------------------AL 298

  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTI 502
            ...:||.|                                             .|:.|..|||.|
Human   299 LEKKKLMA---------------------------------------------ARERKATKTLGI 318

  Fly   503 VMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            ::|..|.||||||:..|::|...........:|. |||:|::|..|||.||...|.||:.||.:|
Human   319 ILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383

  Fly   567  566
            Human   384  383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 75/192 (39%)
TM helix 1 78..101 CDD:410628 8/22 (36%)
TM helix 2 110..132 CDD:410628 10/21 (48%)
TM helix 3 148..170 CDD:410628 12/21 (57%)
TM helix 4 194..210 CDD:410628 6/15 (40%)
TM helix 5 233..256 CDD:410628 6/23 (26%)
7tm_GPCRs <491..563 CDD:475119 30/72 (42%)
TM helix 6 497..519 CDD:320098 12/21 (57%)
TM helix 7 531..556 CDD:320098 11/25 (44%)
HTR1BNP_000854.1 7tmA_5-HT1B_1D 46..380 CDD:320455 134/498 (27%)
TM helix 1 51..77 CDD:320455 9/25 (36%)
TM helix 2 84..110 CDD:320455 11/25 (44%)
TM helix 3 122..152 CDD:320455 18/29 (62%)
DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 146..148 1/1 (100%)
TM helix 4 164..187 CDD:320455 11/24 (46%)
TM helix 5 205..234 CDD:320455 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..281 8/31 (26%)
TM helix 6 307..337 CDD:320455 15/29 (52%)
TM helix 7 348..373 CDD:320455 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 365..369 2/3 (67%)

Return to query results.
Submit another query.