DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TyrRII and HTR1A

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000515.2 Gene:HTR1A / 3350 HGNCID:5286 Length:422 Species:Homo sapiens


Alignment Length:546 Identity:144/546 - (26%)
Similarity:225/546 - (41%) Gaps:143/546 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 DVMATGAGAGKLGVPS----------MNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLT 101
            ||::.|.|......|:          ::...||.....||.:.   .:|...|:||..|:.|:..
Human     2 DVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLG---TLIFCAVLGNACVVAAIAL 63

  Fly   102 TRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLC 166
            .|.|:.|.|..:.:||:||.:|...|:|.:.:..:...|..|.:.||::|:||:|.|:.|||.||
Human    64 ERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128

  Fly   167 AISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQ 231
            ||:||||.|:|.|:.|..||..:|.|.| |.:.|:....|:.||.||| .....:::...|..::
Human   129 AIALDRYWAITDPIDYVNKRTPRRAAAL-ISLTWLIGFLISIPPMLGW-RTPEDRSDPDACTISK 191

  Fly   232 NKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYH 296
            :.||.::|..|:|:|||.:||.:|.:|......|.::.|:..  |:|.          :::.| .
Human   192 DHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKV--EKTG----------ADTRH-G 243

  Fly   297 CTPTKWLPNRKSRWRFNSLHDPPPSAATNAAA------KGHQSSVKCSKCSKCSSATGTAGAGAG 355
            .:|.                 |.|..:.|..:      .|.:|....:.|:..:...|..||.  
Human   244 ASPA-----------------PQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAA-- 289

  Fly   356 AGVVDKTLTFKHQPTFYELVEVSRL-SSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCL 419
                            .|::||.|: :|..|....|.....||            ..|||     
Human   290 ----------------LEVIEVHRVGNSKEHLPLPSEAGPTPC------------APASF----- 321

  Fly   420 GGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMP 484
                              |...:..||||:|.                                 
Human   322 ------------------ERKNERNAEAKRKM--------------------------------- 335

  Fly   485 MRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAIN 548
                ...|:.||.|||.|:||..|.||||||:..|::||......:..|:.. ..|:|:.|..:|
Human   336 ----ALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLN 396

  Fly   549 PFIYAFYNPDFRTAFWRLTCRPICKQ 574
            |.|||::|.||:.||.::.....|:|
Human   397 PVIYAYFNKDFQNAFKKIIKCKFCRQ 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 68/191 (36%)
TM helix 1 78..101 CDD:410628 6/22 (27%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 13/21 (62%)
TM helix 4 194..210 CDD:410628 4/15 (27%)
TM helix 5 233..256 CDD:410628 10/22 (45%)
7tm_GPCRs <491..563 CDD:475119 31/72 (43%)
TM helix 6 497..519 CDD:320098 13/21 (62%)
TM helix 7 531..556 CDD:320098 9/25 (36%)
HTR1ANP_000515.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 5/20 (25%)
7tmA_5-HT1A_vertebrates 37..411 CDD:320453 133/498 (27%)
TM helix 1 38..64 CDD:320453 8/28 (29%)
TM helix 2 71..97 CDD:320453 8/25 (32%)
TM helix 3 109..139 CDD:320453 19/29 (66%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 133..135 1/1 (100%)
TM helix 4 151..173 CDD:320453 8/22 (36%)
TM helix 5 192..221 CDD:320453 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..262 6/54 (11%)
TM helix 6 338..368 CDD:320453 17/29 (59%)
TM helix 7 379..404 CDD:320453 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 396..400 2/3 (67%)

Return to query results.
Submit another query.