DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and HRH2

DIOPT Version :9

Sequence 1:NP_001262682.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_001354640.1 Gene:HRH2 / 3274 HGNCID:5183 Length:422 Species:Homo sapiens


Alignment Length:528 Identity:115/528 - (21%)
Similarity:175/528 - (33%) Gaps:223/528 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 NSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVM 128
            :|:.:.....|.....|..|:||:||.||.:|.|||...||||.:||||:::|||||.|:|..|:
Human     8 SSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVL 72

  Fly   129 PPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLAL 193
            |.|.:..::..|.||.:.|:|:.|||::||:.|||:|..||||||.||..||.|.......|:|:
Human    73 PFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137

  Fly   194 LMILVVWITALSIT-CPPYLGW-----YEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVML 252
            .::| :|:.::::: ...:|||     ...|.|...  .|:...|:.|.:...:.:|::||.:|.
Human   138 SLVL-IWVISITLSFLSIHLGWNSRNETSKGNHTTS--KCKVQVNEVYGLVDGLVTFYLPLLIMC 199

  Fly   253 YVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHD 317
            ..|.:|..|...:.:||                                   |..|.|:      
Human   200 ITYYRIFKVARDQAKRI-----------------------------------NHISSWK------ 223

  Fly   318 PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSS 382
                                                                             
Human   224 ----------------------------------------------------------------- 223

  Fly   383 LIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEA 447
                                                                             
Human   224 ----------------------------------------------------------------- 223

  Fly   448 KQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512
                                                    :.|.|:.|...||..|||..|.||.
Human   224 ----------------------------------------AATIREHKATVTLAAVMGAFIICWF 248

  Fly   513 PFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRP 577
            |:|..::........|:.|.|.....|:|:.|.|:||.:||..|.||||.:.:|.|   |:....
Human   249 PYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFC---CRLANR 310

  Fly   578 PNHLAMFR 585
            .:|....|
Human   311 NSHKTSLR 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_001262682.1 7tm_4 82..>212 CDD:304433 58/130 (45%)
7tm_1 91..>277 CDD:278431 70/191 (37%)
HRH2NP_001354640.1 7tmA_Histamine_H2R 19..299 CDD:320179 108/493 (22%)
TM helix 1 21..45 CDD:320179 12/23 (52%)
TM helix 2 54..76 CDD:320179 12/21 (57%)
TM helix 3 92..114 CDD:320179 11/21 (52%)
TM helix 4 137..153 CDD:320179 2/16 (13%)
TM helix 5 180..203 CDD:320179 5/22 (23%)
TM helix 6 233..255 CDD:320179 10/21 (48%)
TM helix 7 267..292 CDD:320179 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340 1/3 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.870

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