DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Htr2b

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_058946.2 Gene:Htr2b / 29581 RGDID:61801 Length:479 Species:Rattus norvegicus


Alignment Length:507 Identity:120/507 - (23%)
Similarity:182/507 - (35%) Gaps:182/507 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVV-LYITGTW 140
            |:.:|.||| .|:.||.||||||...:||:..||.|:|:||:.|.|||..|||.::: :....||
  Rat    57 ALLIFAVII-PTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATW 120

  Fly   141 RFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALS 205
            .....||..|:.||:|..:.||:.|||||||||:|:.:|: .:.:..|:..|.:.|.|||:.::.
  Rat   121 PLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPI-QANQCNSRTTAFVKITVVWLISIG 184

  Fly   206 ITCPPYLGWYEVGRHQAEFVDCRYNQNK--GYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQR 268
            |..|..:...|.....|..:.|...:::  .:::|.::.:||.|||:|:     :.|.||....|
  Rat   185 IAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMI-----VTYFLTIHALR 244

  Fly   269 IVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQS 333
              :.||..|...                       |.|.:||                       
  Rat   245 --KKAYLVRNRP-----------------------PQRLTRW----------------------- 261

  Fly   334 SVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCM 398
                                                                             
  Rat   262 ----------------------------------------------------------------- 261

  Fly   399 HSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHP 463
                                            |.:||.               |::.|||.....
  Rat   262 --------------------------------TVSTVL---------------QREDSSFSSPEK 279

  Fly   464 HAHHHGSHGQQSHHNHHHRMPMR---------VSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYL 519
            .|...|||..:...|......||         ..|...:.:.:|.|.||....:..|.|||:..:
  Rat   280 MAMLDGSHKDKILPNSIDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNV 344

  Fly   520 LIPFLP--RPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWR-LTC 568
            .:....  ....|:.|:..|.|:|:|:..:||.||..:|..||.||.| :||
  Rat   345 TLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITC 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 71/194 (37%)
TM helix 1 78..101 CDD:410628 13/22 (59%)
TM helix 2 110..132 CDD:410628 12/21 (57%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 5/15 (33%)
TM helix 5 233..256 CDD:410628 7/24 (29%)
7tm_GPCRs <491..563 CDD:475119 21/73 (29%)
TM helix 6 497..519 CDD:320098 8/21 (38%)
TM helix 7 531..556 CDD:320098 9/24 (38%)
Htr2bNP_058946.2 7tm_GPCRs 54..397 CDD:475119 120/507 (24%)
TM helix 1 56..80 CDD:410628 14/23 (61%)
TM helix 2 89..111 CDD:410628 12/21 (57%)
TM helix 3 128..150 CDD:410628 10/21 (48%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 151..153 1/1 (100%)
TM helix 4 173..189 CDD:410628 5/15 (33%)
[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000250|UniProtKB:P41595 211..214 0/2 (0%)
TM helix 5 214..237 CDD:410628 7/27 (26%)
TM helix 6 322..344 CDD:410628 8/21 (38%)
TM helix 7 358..383 CDD:410628 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 375..379 2/3 (67%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P41595 477..479
Blue background indicates that the domain is not in the aligned region.

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