Protein Alignment TyrRII and Adra1a

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_058887.2
• Gene: Adra1a / 29412
• RGDID: 2055
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 130/526 - (24%)
• Similarity: 207/526 - (39%)
• Gaps: 204/526 - (38%)

  Fly    73 PKSLAVAVFLVIIL-----VTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSV 132
            |.:::.|:.|.:||     ..|:||.||||:|...|.|.:||:.:::|||:.|.|:.:.|:|.|.
  Rat    20 PVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84

  Fly   133 VLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYS---KKRRSKRLALL 194
            :..|.|.|.||.:.|:||.::|:|.|:.||:.||.||:|||:.|:.||.|.   .:||..|
  Rat    85 IFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVR---- 145

  Fly   195 MILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIG 259
            .:|.||:.:|.|:..|..||.:........  |:.|:..|||:|||:|||::||.::|.:|.::
  Rat   146 ALLCVWVLSLVISIGPLFGWRQPAPEDETI--CQINEEPGYVLFSALGSFYVPLAIILVMYCRV- 207

  Fly   260 YVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAAT 324
            ||:..|..|
  Rat   208 YVVAKRESR-------------------------------------------------------- 216

  Fly   325 NAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAI 389
                 |.:|.:|..|.                                   :..:::..||...:
  Rat   217 -----GLKSGLKTDKS-----------------------------------DSEQVTLRIHRKNV 241

  Fly   390 SCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQ 454
            ..:                           ||.||:                     ||.|
  Rat   242 PAE---------------------------GGGVSS---------------------AKNK---- 254

  Fly   455 RSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYL 519
                                :|.:      :|:....|:.|.||||.||:|..:.||||||   |
  Rat   255 --------------------THFS------VRLLKFSREKKAAKTLGIVVGCFVLCWLPFF---L 290

  Fly   520 LIP-------FLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRP 577
            ::|       |.|...|.: ::|   |:|::|..|||.||...:.:|:.||..: .|..|.::|.
  Rat   291 VMPIGSFFPDFKPSETVFK-IVF---WLGYLNSCINPIIYPCSSQEFKKAFQNV-LRIQCLRRRQ 350

  Fly   578 PNHLAM 583
            .:..|:
  Rat   351 SSKHAL 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	56/137 (41%)
		7tm_1	91..>277	CDD:278431	73/188 (39%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	122/497 (25%)
		TM helix 1	29..53	CDD:320448	11/23 (48%)
		TM helix 2	62..84	CDD:320448	7/21 (33%)
		TM helix 3	100..122	CDD:320448	10/21 (48%)
		TM helix 4	145..161	CDD:320448	6/19 (32%)
		TM helix 5	182..205	CDD:320448	12/22 (55%)
		TM helix 6	271..293	CDD:320448	14/24 (58%)
		TM helix 7	305..330	CDD:320448	10/28 (36%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		4/15 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010