Protein Alignment TyrRII and adra2da

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_919345.2
• Gene: adra2da / 266754
• ZFINID: ZDB-GENE-021010-4
• Length: 408
• Species: Danio rerio
• Alignment Length: 511
• Identity: 145/511 - (28%)
• Similarity: 215/511 - (42%)
• Gaps: 145/511 - (28%)

  Fly    72 WP-----KSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPS 131
            ||     .::.:.|..:|||:|:|||.|||:||||:|.||...|.|:::||..|.||.|.|:|.|
Zfish    23 WPYTEPASAIIILVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFS 87

  Fly   132 VVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMI 196
            :...|.|.|.||...|..:::||:|.|:.||:.|||||||||.:||:.:.|:.||..:|:. .||
Zfish    88 LANEIMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIK-CMI 151

  Fly   197 LVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYV 261
            .|||:.:..|:.||.:    :.:|..:  :|..|....|::.|...|||.|..:|:.||.|| |.
Zfish   152 AVVWLISAVISFPPLI----MTKHDEK--ECLINDETWYILSSCAVSFFAPGLIMITVYCKI-YR 209

  Fly   262 LTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNA 326
            :..:|...|                 |:::                     |.|...|..:.|..
Zfish   210 VAKQRSSTV-----------------FVAK---------------------NGLERQPSQSETCF 236

  Fly   327 AAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISC 391
            ..|.     |..|.|..|:::.:|               :.|.   ||.::..
Zfish   237 VRKD-----KFEKESPSSNSSESA---------------QRQE---ELDDIDL------------ 266

  Fly   392 KYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRS 456
                              .|::.||:...|:             ......::|.|.:..|:..|.
Zfish   267 ------------------EESAASDSRARGS-------------RFSKRRRVEGERRGPQRSCRV 300

  Fly   457 SF-DHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTK----RDSKTAKTLTIVMGGLIACWLPFFV 516
            |: .|..|     ||..||           ..|.:|    |:.:....|.:|||..:.||.|||.
Zfish   301 SWAAHQEP-----GSRQQQ-----------LASKSKVAQMREKRFTFVLAVVMGVFVLCWFPFFF 349

  Fly   517 YYLLIPFLPR----PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTC 568
            .|.|......    |..|..|.|   |||:.|.::||.||..:|.|||.||.::.|
Zfish   350 TYSLQAVCGERCGPPEALFKLFF---WIGYCNSSVNPIIYTIFNRDFRKAFKKVVC 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	80/191 (42%)
		TM helix 1	78..101	CDD:410628	13/22 (59%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	8/22 (36%)
		7tm_GPCRs	<491..563	CDD:475119	29/79 (37%)
		TM helix 6	497..519	CDD:320098	9/21 (43%)
		TM helix 7	531..556	CDD:320098	10/24 (42%)
adra2da	NP_919345.2	7tmA_alpha-2D_AR	44..397	CDD:320447	136/483 (28%)
		TM helix 2	65..91	CDD:320447	11/25 (44%)
		TM helix 3	103..133	CDD:320447	16/29 (55%)
		TM helix 4	145..168	CDD:320447	9/27 (33%)
		TM helix 5	181..210	CDD:320447	12/29 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..306		16/124 (13%)
		TM helix 6	324..354	CDD:320447	11/29 (38%)
		TM helix 7	365..390	CDD:320447	11/27 (41%)