DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TyrRII and adra2b

DIOPT Version :9

Sequence 1:	NP_001262682.1	Gene:	TyrRII / 42135	FlyBaseID:	FBgn0038541	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_997521.1	Gene:	adra2b / 266751	ZFINID:	ZDB-GENE-021010-2	Length:	510	Species:	Danio rerio

Alignment Length:	569	Identity:	153/569 - (26%)
Similarity:	238/569 - (41%)	Gaps:	135/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GAGKLGVPSMNSYLVSMAWPKSLAVAVF----LVIILVTVVGNTLVILAVLTTRRLRTVTNCFVM 114
            |.|....|:.|..::.:|.....|.|.|    .:::|:|:|||.|||:||||:|.||...|.|::
Zfish    17 GTGGTSSPTCNQSMIKLAPYSPEATAAFATAITLMMLITIVGNILVIIAVLTSRSLRGPQNLFLV 81

  Fly   115 NLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQP 179
            :||..|.||.|.::|.|:...:.|.|.|..:.|:|:::||:|.|:.||:.|||||||||:::::.
Zfish    82 SLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLFCTSSIVHLCAISLDRYMSISRA 146

  Fly   180 LTYSKKRRSKRLALLMILVVWITALSITCPPYLGW--YEVGRHQAEFVDCRYNQNKGYVVFSAMG 242
            :||..||..||:. ..|||||:.:..|:.||.|..  .:.|........|:.|..:.|:::|.:|
Zfish   147 VTYGPKRTPKRIK-CAILVVWLISAVISFPPLLSMNKNKGGGESGALPQCQLNDERWYILYSTIG 210

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRK 307
            |||.|..:|:.||::| |.:..:|.|                            |.|
Zfish   211 SFFAPCLIMILVYMRI-YQIAKQRTR----------------------------CPP-------- 238

  Fly   308 SRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
                    .:|...|..||....|          |..:..|....|        ||..|.:|...
Zfish   239 --------GEPRKEAPANATTPQH----------KIQNGRGDETPG--------TLQKKARPPTL 277

  Fly   373 ELVEVSRL---------SSLIHCSAISCKYGGPCMHSTPSGMHYVG------------------- 409
            .:.:|..:         ::|:...:.:.....||...:||....|.
Zfish   278 AVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCPSPSPSNSSEVAPSKSKEGKKEKKKKKNNKN 342

  Fly   410 ------------TEASFSDTCLGG---NVSNNTTTTTTNTVALETNEK---LEAEAKQKQQQQRS 456
                        :.:|.|||..||   .|....|.|.:...:..|.:|   :.|.||..:...|.
Zfish   343 KNKKEPDNNNGESMSSDSDTEQGGRGLEVPCTPTMTPSGIHSPATMQKYRDMIATAKGAKLVARK 407

  Fly   457 SFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLI 521
            :.....|::                  ..|.:...|:.:....|.:|:|..:.||.|||..|.|.
Zfish   408 AKQDGTPNS------------------ARRKAMVNREKRFTFVLAVVIGVFVICWFPFFFSYSLQ 454

  Fly   522 PFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCR 569
            ...|....|.:.:|. |.|||:.|..:||.||..:|.|||.||.::.|:
Zfish   455 AVCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKILCK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	59/129 (46%)
TyrRII	NP_001262682.1	7tm_1	91..>277	CDD:278431	74/187 (40%)
adra2b	NP_997521.1	7tm_4	50..>178	CDD:304433	59/128 (46%)
		7tm_1	58..>244	CDD:278431	77/231 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..284		16/111 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..385		14/84 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910