DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and adra2b

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_997521.2 Gene:adra2b / 266751 ZFINID:ZDB-GENE-021010-2 Length:509 Species:Danio rerio


Alignment Length:568 Identity:153/568 - (26%)
Similarity:238/568 - (41%) Gaps:134/568 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 GAGKLGVPSMNSYLVSMAWPKSLAVAVF----LVIILVTVVGNTLVILAVLTTRRLRTVTNCFVM 114
            |.|....|:.|..::.:|.....|.|.|    .:::|:|:|||.|||:||||:|.||...|.|::
Zfish    17 GTGGTSSPTCNQSMIKLAPYSPEATAAFATAITLMMLITIVGNILVIIAVLTSRSLRGPQNLFLV 81

  Fly   115 NLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQP 179
            :||..|.||.|.::|.|:...:.|.|.|..:.|:|:::||:|.|:.||:.|||||||||:::::.
Zfish    82 SLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLFCTSSIVHLCAISLDRYMSISRA 146

  Fly   180 LTYSKKRRSKRLALLMILVVWITALSITCPPYLGW--YEVGRHQAEFVDCRYNQNKGYVVFSAMG 242
            :||..||..||:. ..|||||:.:..|:.||.|..  .:.|........|:.|..:.|:::|.:|
Zfish   147 VTYGPKRTPKRIK-CAILVVWLISAVISFPPLLSMNKNKGGGESGALPQCQLNDERWYILYSTIG 210

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRK 307
            |||.|..:|:.||::| |.:..:|.|                            |.|        
Zfish   211 SFFAPCLIMILVYMRI-YQIAKQRTR----------------------------CPP-------- 238

  Fly   308 SRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
                    .:|...|..||....|          |..:..|....|        ||..|.:|...
Zfish   239 --------GEPRKEAPANATTPQH----------KIQNGRGDETPG--------TLQKKARPPTL 277

  Fly   373 ELVEVSRL---------SSLIHCSAISCKYGGPCMHSTPSGMHYVG------------------- 409
            .:.:|..:         ::|:...:.:.....||...:||....|.                   
Zfish   278 AVSQVESVQQAANTPIANNLLQAPSTTLTPTTPCPSPSPSNSSEVAPSKSKEGKKEKKKKNNKNK 342

  Fly   410 -----------TEASFSDTCLGG---NVSNNTTTTTTNTVALETNEK---LEAEAKQKQQQQRSS 457
                       :.:|.|||..||   .|....|.|.:...:..|.:|   :.|.||..:...|.:
Zfish   343 NKKEPDNNNGESMSSDSDTEQGGRGLEVPCTPTMTPSGIHSPATMQKYRDMIATAKGAKLVARKA 407

  Fly   458 FDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIP 522
            .....|::                  ..|.:...|:.:....|.:|:|..:.||.|||..|.|..
Zfish   408 KQDGTPNS------------------ARRKAMVNREKRFTFVLAVVIGVFVICWFPFFFSYSLQA 454

  Fly   523 FLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCR 569
            ..|....|.:.:|. |.|||:.|..:||.||..:|.|||.||.::.|:
Zfish   455 VCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKILCK 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 79/197 (40%)
TM helix 1 78..101 CDD:410628 12/26 (46%)
TM helix 2 110..132 CDD:410628 9/21 (43%)
TM helix 3 148..170 CDD:410628 11/21 (52%)
TM helix 4 194..210 CDD:410628 6/15 (40%)
TM helix 5 233..256 CDD:410628 9/22 (41%)
7tm_GPCRs <491..563 CDD:475119 27/72 (38%)
TM helix 6 497..519 CDD:320098 8/21 (38%)
TM helix 7 531..556 CDD:320098 10/25 (40%)
adra2bNP_997521.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..284 16/111 (14%)

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