DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and adra2a

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_997520.4 Gene:adra2a / 266750 ZFINID:ZDB-GENE-021010-1 Length:388 Species:Danio rerio


Alignment Length:533 Identity:149/533 - (27%)
Similarity:226/533 - (42%) Gaps:153/533 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 MATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFV 113
            |..||.|.. |..:...|.:.:|.|  |:|||.|:|:|: :.||.|||:||.|:|.||...|.|:
Zfish     1 MICGANATN-GTNATKEYTLLVALP--LSVAVGLLILLI-IFGNVLVIIAVFTSRALRAPQNLFL 61

  Fly   114 MNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQ 178
            ::||..|.||.|.|||.|:...:.|.|.||.:.|:|:::||:|.|:.||..|||||||||.::||
Zfish    62 VSLASADILVATLVMPFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQ 126

  Fly   179 PLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGS 243
            .:.|:.||..:|:..: |.:|||.|..|:|||.     :...::|...|..|:.|.|:|.|.:||
Zfish   127 AIEYNLKRTPQRIKRI-IFIVWIIAAVISCPPL-----ITMKKSEGDICDINKEKWYIVSSCIGS 185

  Fly   244 FFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGD---NFISESEHYHCTPTKWLPN 305
            ||:|..:|:.||::| |.:..:|.|.             ..||   |.:.:.|:.        |:
Zfish   186 FFLPCIIMVLVYIRI-YQIAKKRTRA-------------PPGDHRKNEVGKKEND--------PH 228

  Fly   306 RKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPT 370
            .|    .|.:.:..|.                                      ||.        
Zfish   229 EK----LNGIQNAEPE--------------------------------------DKD-------- 243

  Fly   371 FYEL--VEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTN 433
              |:  |::...||..|      |...||                        ::...::...|.
Zfish   244 --EINGVDMEESSSSDH------KVSNPC------------------------SLKKKSSKGKTK 276

  Fly   434 TVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAK 498
            ...::..:..:.||.|..:..|..              |:|:                |:.:...
Zfish   277 LSQIKPGDGDKTEACQTTKASRWK--------------GRQN----------------REKRFTF 311

  Fly   499 TLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF 563
            .|.:|:|..:.||.|||..|....|.. ..|.|.|...|.|.|:.|.::||.||..:|.|||.:|
Zfish   312 VLAVVIGVFVICWFPFFFTYTFTAFCD-CCVPETLFKFFFWFGYCNSSLNPIIYTIFNNDFRRSF 375

  Fly   564 WRLTCRPICKQKR 576
            .::.||   :.||
Zfish   376 KKILCR---RDKR 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 84/191 (44%)
TM helix 1 78..101 CDD:410628 13/22 (59%)
TM helix 2 110..132 CDD:410628 11/21 (52%)
TM helix 3 148..170 CDD:410628 11/21 (52%)
TM helix 4 194..210 CDD:410628 7/15 (47%)
TM helix 5 233..256 CDD:410628 11/22 (50%)
7tm_GPCRs <491..563 CDD:475119 26/71 (37%)
TM helix 6 497..519 CDD:320098 8/21 (38%)
TM helix 7 531..556 CDD:320098 10/24 (42%)
adra2aNP_997520.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..291 21/185 (11%)

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