Protein Alignment TyrRII and Htr4

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_036985.2
• Gene: Htr4 / 25324
• RGDID: 2850
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 518
• Identity: 118/518 - (22%)
• Similarity: 180/518 - (34%)
• Gaps: 211/518 - (40%)

  Fly    74 KSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTV-TNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |.:.:..|.::||:.::||.||::||...|:||.: ||.|:::||..|.||...|||...:..:.
  Rat    19 KVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQ 83

  Fly   138 GTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAV-TQPLTYSKKRRSKRLALLMILVVWI 201
            ..|.:|.:.|.:..|||:||.:.||..||.||||||.|: .|||.|..|....|:| ||:...|:
  Rat    84 DIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIA-LMLGGCWV 147

  Fly   202 TALSITCPPYL-GWYEVG----------RHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVY 255
            ..:.|:..|.: ||..:|          .|.:....|.:..||.|.:..::.:|:||..:|:..|
  Rat   148 IPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAY 212

  Fly   256 VKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPP 320
            .:|                             :::..||
  Rat   213 YRI-----------------------------YVTAKEH-------------------------- 222

  Fly   321 SAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIH 385
                                                                             
  Rat   223 ----------------------------------------------------------------- 222

  Fly   386 CSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQK 450
                                                                         |:|.
  Rat   223 -------------------------------------------------------------AQQI 226

  Fly   451 QQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFF 515
            |..||:.....        |..|.:..:..|||       :.::|.||||.::||....||.|||
  Rat   227 QMLQRAGATSE--------SRPQTADQHSTHRM-------RTETKAAKTLCVIMGCFCFCWAPFF 276

  Fly   516 VYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQKRPP 578
            |..::.||:.. .|.|.:...|.|:|::|..:|||:|||.|..||.||..:.|....:.||||
  Rat   277 VTNIVDPFIDY-TVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPP 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	68/204 (33%)
		TM helix 1	78..101	CDD:410628	9/22 (41%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	10/21 (48%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	6/22 (27%)
		7tm_GPCRs	<491..563	CDD:475119	30/71 (42%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	11/24 (46%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	110/500 (22%)
		TM helix 1	21..47	CDD:320184	9/25 (36%)
		TM helix 2	55..81	CDD:320184	11/25 (44%)
		TM helix 3	93..123	CDD:320184	17/29 (59%)
		TM helix 4	136..159	CDD:320184	7/23 (30%)
		TM helix 5	189..218	CDD:320184	9/57 (16%)
		TM helix 6	252..282	CDD:320184	13/29 (45%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)