DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and Htr1d

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_036984.1 Gene:Htr1d / 25323 RGDID:2847 Length:374 Species:Rattus norvegicus


Alignment Length:520 Identity:150/520 - (28%)
Similarity:209/520 - (40%) Gaps:174/520 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 GVP---SMNSYLVSMAW-PKSL------AVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFV 113
            |:|   |..|...:.|| |:.|      .|.|..:|.|.||:.|..|:..:|.|::|.|..|..:
  Rat    10 GLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLI 74

  Fly   114 MNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQ 178
            .:||.||.||...|||.|:....|.||.||.||||||:|.||..|:.|||.||.|:||||.|:|.
  Rat    75 GSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITD 139

  Fly   179 PLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNK-GYVVFSAMG 242
            .|.|| |||:...|..||..||..::.|:.|| |.|.:...|: |..||..|.:: .|.::|..|
  Rat   140 ALEYS-KRRTAGHAAAMIAAVWAISICISIPP-LFWRQATAHE-EMSDCLVNTSQISYTIYSTCG 201

  Fly   243 SFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRK 307
            :|:||..:::.:|   |.:..:.|.||:                                     
  Rat   202 AFYIPSILLIILY---GRIYVAARSRIL------------------------------------- 226

  Fly   308 SRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFY 372
                     :||              |:...:.:.....||:||                     
  Rat   227 ---------NPP--------------SLYGKRFTTAQLITGSAG--------------------- 247

  Fly   373 ELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVAL 437
                    |||  ||.      .|.:|.  |..|.||:...|                  |.|.:
  Rat   248 --------SSL--CSL------NPSLHE--SHTHTVGSPLFF------------------NQVKI 276

  Fly   438 ETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTI 502
            :..:.: .|.|                                     |:|.. |:.|..|||.|
  Rat   277 KLADSI-LERK-------------------------------------RISAA-RERKATKTLGI 302

  Fly   503 VMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            ::|..|.|||||||..|::|.......:...:|. |||:|::|..|||.||..:|.|||.||.|:
  Rat   303 ILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRV 367

  Fly   567  566
              Rat   368  367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 81/192 (42%)
TM helix 1 78..101 CDD:410628 8/22 (36%)
TM helix 2 110..132 CDD:410628 10/21 (48%)
TM helix 3 148..170 CDD:410628 13/21 (62%)
TM helix 4 194..210 CDD:410628 5/15 (33%)
TM helix 5 233..256 CDD:410628 6/23 (26%)
7tm_GPCRs <491..563 CDD:475119 32/72 (44%)
TM helix 6 497..519 CDD:320098 13/21 (62%)
TM helix 7 531..556 CDD:320098 11/25 (44%)
Htr1dNP_036984.1 7tmA_5-HT1B_1D 32..364 CDD:320455 139/493 (28%)
TM helix 1 37..63 CDD:320455 9/25 (36%)
TM helix 2 70..96 CDD:320455 11/25 (44%)
TM helix 3 108..138 CDD:320455 19/29 (66%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 132..134 1/1 (100%)
TM helix 4 150..173 CDD:320455 9/23 (39%)
TM helix 5 191..220 CDD:320455 8/31 (26%)
TM helix 6 291..321 CDD:320455 16/30 (53%)
TM helix 7 332..357 CDD:320455 11/24 (46%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 349..353 2/3 (67%)

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