Protein Alignment TyrRII and Chrm1

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_542951.1
• Gene: Chrm1 / 25229
• RGDID: 2342
• Length: 460
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 130/565 - (23%)
• Similarity: 203/565 - (35%)
• Gaps: 166/565 - (29%)

  Fly    38 IQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTT 102
            :..:.:|...|:|.|.|..::....:.:.|:|:|                ||.||.||:::....
  Rat     5 VPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLA----------------TVTGNLLVLISFKVN 53

  Fly   103 RRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCA 167
            ..|:||.|.|:::||..|.::||..|.......:.|.|..|.:.||:|::||.:..:.|:::|..
  Rat    54 TELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLL 118

  Fly   168 ISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGW-YEVGRHQAEFVDCRYNQ 231
            ||.|||.:||:||:|..||..:| |.|||.:.|:.:..:..|..|.| |.||........|
  Rat   119 ISFDRYFSVTRPLSYRAKRTPRR-AALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQC---- 178

  Fly   232 NKGYVVF---------SAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDN 287
               |:.|         :||.:|::|:|||..:|.:| |..|..|.|.:.......|..   .|..
  Rat   179 ---YIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRI-YRETENRARELAALQGSETPG---KGGG 236

  Fly   288 FISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKC--------- 343
            ..|.||             :|:.......:.||.              :|.:|.:.
  Rat   237 SSSSSE-------------RSQPGAEGSPESPPG--------------RCCRCCRAPRLLQAYSW 274

  Fly   344 -----------SSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPC 397
                       .|.|.:.|...|:.||.|
  Rat   275 KEEEEEDEGSMESLTSSEGEEPGSEVVIK------------------------------------ 303

  Fly   398 MHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHH 462
                   |..|.:||                               :|..||..:...::.....
  Rat   304 -------MPMVDSEA-------------------------------QAPTKQPPKSSPNTVKRPT 330

  Fly   463 PHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR- 526
            ......|..||:.............|..| :.|.|:||:.::...|..|.|:.:..|:..|...
  Rat   331 KKGRDRGGKGQKPRGKEQLAKRKTFSLVK-EKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC 394

  Fly   527 -PAVLEDLMFGFTWIGWVNCAINPFIYAFYNPDFRTAF-WRLTCR 569
             |..|.:|.:   |:.:||..:||..||..|..||..| ..|.||
  Rat   395 VPETLWELGY---WLCYVNSTVNPMCYALCNKAFRDTFRLLLLCR 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	67/201 (33%)
		TM helix 1	78..101	CDD:410628	6/22 (27%)
		TM helix 2	110..132	CDD:410628	8/21 (38%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	9/31 (29%)
		7tm_GPCRs	<491..563	CDD:475119	23/73 (32%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
Chrm1	NP_542951.1	7tmA_mAChR_M1	26..429	CDD:341356	121/535 (23%)
		TM helix 1	27..53	CDD:341356	9/41 (22%)
		TM helix 2	60..86	CDD:341356	8/25 (32%)
		TM helix 3	98..128	CDD:341356	12/29 (41%)
		TM helix 4	140..163	CDD:341356	7/23 (30%)
		TM helix 5	185..214	CDD:341356	10/29 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..257		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..297		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..351		8/71 (11%)
		TM helix 6	358..388	CDD:341356	9/30 (30%)
		TM helix 7	397..422	CDD:341356	9/27 (33%)