Protein Alignment TyrRII and Adra2a

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_036871.3
• Gene: Adra2a / 25083
• RGDID: 2056
• Length: 465
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 164/609 - (26%)
• Similarity: 230/609 - (37%)
• Gaps: 206/609 - (33%)

  Fly     1 MAALEHPDAMLPYSKLLSTALTVASGNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNS 65
            |.:|: |||                ||| |.:||       .||||...||
  Rat    16 MGSLQ-PDA----------------GNS-SWNGT-------EAPGGGTRAT-------------- 41

  Fly    66 YLVSMAWPKSLAVAVFLV-----IILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGT 125
                   |.||.|.:.||     ::|.||.||.|||:||.|:|.|:...|.|:::||..|.||.|
  Rat    42 -------PYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVAT 99

  Fly   126 CVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKR 190
            .|:|.|:...:.|.|.||.:.|:|:::||:|.|:.||:.|||||||||.::||.:.|:.||..:|
  Rat   100 LVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRR 164

  Fly   191 LALLMILVVWITALSITCPPYLGWYEVGR---HQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVML 252
            :..: |:.||:.:..|:.||.:...:.|.   .|.....|:.|..|.||:.|::||||.|..:|:
  Rat   165 IKAI-IVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMI 228

  Fly   253 YVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHD 317
            .|||:| |.:..||.|:
  Rat   229 LVYVRI-YQIAKRRTRV------------------------------------------------ 244

  Fly   318 PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTA-------GAGAGAGVVDKTLTFKHQPTFYELV 375
            ||.....:|                ||:..|.|       |...|||.
  Rat   245 PPSRRGPDA----------------CSAPPGGADRRPNGLGPERGAGT----------------- 276

  Fly   376 EVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETN 440
                                            .|.||....|.|.|.......|...:..||:..
  Rat   277 --------------------------------AGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLE 309

  Fly   441 EKLEAE--------------------AKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPM 485
            |...:|                    .|..|.:...|.....|.|...|:.|  |..........
  Rat   310 ESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASG--SGQGEERAGGA 372

  Fly   486 RVSTTK----RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPF-LPRPAVLEDLMFGFTWIGWVNC 545
            :.|..:    |:.:....|.:|:|..:.||.|||..|.||.. .|.|..|.:..|   |.|:.|.
  Rat   373 KASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFF---WFGYCNS 434

  Fly   546 AINPFIYAFYNPDFRTAFWRLTCR 569
            ::||.||..:|.|||.||.::.||
  Rat   435 SLNPVIYTIFNHDFRRAFKKILCR 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	59/134 (44%)
		7tm_1	91..>277	CDD:278431	76/188 (40%)
Adra2a	NP_036871.3	7tmA_alpha2A_AR	49..452	CDD:320445	139/522 (27%)
		TM helix 1	51..75	CDD:320445	12/23 (52%)
		TM helix 2	84..106	CDD:320445	10/21 (48%)
		TM helix 3	122..144	CDD:320445	11/21 (52%)
		TM helix 4	167..183	CDD:320445	4/16 (25%)
		TM helix 5	209..232	CDD:320445	11/22 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..377		32/249 (13%)
		PRK07764	<243..>365	CDD:236090	31/236 (13%)
		TM helix 6	388..410	CDD:320445	8/21 (38%)
		TM helix 7	420..445	CDD:320445	9/27 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910