Protein Alignment TyrRII and Htr1b

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_071561.1
• Gene: Htr1b / 25075
• RGDID: 2846
• Length: 386
• Species: Rattus norvegicus
• Alignment Length: 524
• Identity: 141/524 - (26%)
• Similarity: 209/524 - (39%)
• Gaps: 179/524 - (34%)

  Fly    59 GVP--------SMNSYL----VSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNC 111
            |||        |.:.|:    :::.| |.|.||:..:|.|.|.:.|..||..|..||:|.|..|.
  Rat    19 GVPLANLSHNCSADDYIYQDSIALPW-KVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANY 82

  Fly   112 FVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAV 176
            .:.:||:||.||...|||.|.:..:||.|..|.::||.|:|.||..|:.||:.||.|:||||.|:
  Rat    83 LIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAI 147

  Fly   177 TQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKG-YVVFSA 240
            |..:.||.||..|| |.:||::||:.::||:.||:. |.: .:.:.|.:||..|.:.. |.|:|.
  Rat   148 TDAVDYSAKRTPKR-AAIMIVLVWVFSISISLPPFF-WRQ-AKAEEEVLDCFVNTDHVLYTVYST 209

  Fly   241 MGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPN 305
            :|:|::|..:::.:|   |.:....|.||::.                         ||.|   .
  Rat   210 VGAFYLPTLLLIALY---GRIYVEARSRILKQ-------------------------TPNK---T 243

  Fly   306 RKSRWRFNSLHDPPPSAATNAAAKGHQSSVKC--SKCSKCSSATGTAGAGAGAGVVDKTLTFKHQ 368
            .|...|...:.|.|          |..|||..  |:..:..|.:|:
  Rat   244 GKRLTRAQLITDSP----------GSTSSVTSINSRVPEVPSESGS------------------- 279

  Fly   369 PTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTN 433
            |.:...|:| |:|.
  Rat   280 PVYVNQVKV-RVSD--------------------------------------------------- 292

  Fly   434 TVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAK 498
              ||...:||.|                                             .|:.|..|
  Rat   293 --ALLEKKKLMA---------------------------------------------ARERKATK 310

  Fly   499 TLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFG-FTWIGWVNCAINPFIYAFYNPDFRTA 562
            ||.|::|..|.||||||:..|::|...........:|. |.|:|::|..|||.||...|.||:.|
  Rat   311 TLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQA 375

  Fly   563 FWRL 566
            |.:|
  Rat   376 FHKL 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	76/192 (40%)
		TM helix 1	78..101	CDD:410628	9/22 (41%)
		TM helix 2	110..132	CDD:410628	10/21 (48%)
		TM helix 3	148..170	CDD:410628	11/21 (52%)
		TM helix 4	194..210	CDD:410628	6/15 (40%)
		TM helix 5	233..256	CDD:410628	6/23 (26%)
		7tm_GPCRs	<491..563	CDD:475119	29/72 (40%)
		TM helix 6	497..519	CDD:320098	12/21 (57%)
		TM helix 7	531..556	CDD:320098	10/25 (40%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	133/496 (27%)
		TM helix 1	47..73	CDD:320455	10/25 (40%)
		TM helix 2	80..106	CDD:320455	11/25 (44%)
		TM helix 3	118..148	CDD:320455	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	11/24 (46%)
		TM helix 5	201..230	CDD:320455	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..276		7/30 (23%)
		TM helix 6	303..333	CDD:320455	15/29 (52%)
		TM helix 7	344..369	CDD:320455	10/24 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		2/3 (67%)