Protein Alignment TyrRII and Chrm2

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_987076.2
• Gene: Chrm2 / 243764
• MGIID: 88397
• Length: 466
• Species: Mus musculus
• Alignment Length: 544
• Identity: 128/544 - (23%)
• Similarity: 213/544 - (39%)
• Gaps: 120/544 - (22%)

  Fly    62 SMNSYLVSMAWPKSLAVAVFLVII-----LVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDW 121
            |.|:.|...:..|:..| ||:|::     |||::||.||::::...|.|:||.|.|:.:||..|.
Mouse     7 SSNNGLAITSPYKTFEV-VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADL 70

  Fly   122 LVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKR 186
            ::|...|....:..:.|.|..|.::||:|::||.::.:.|:::|..||.|||..||:||||..||
Mouse    71 IIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKR 135

  Fly   187 RSKRLALLMILVVWITALSITCPPYLGW-YEVGRHQAEFVDC--RYNQNKGYVVFSAMGSFFIPL 248
            .:| :|.:||...|:.:..:..|..|.| :.||....|..:|  ::..|......:|:.:|::|:
Mouse   136 TTK-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPV 199

  Fly   249 TVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYD------VDGDNFISESEHYHCTPTKWLPNRK 307
            .:|..:|..|.....||    ::....|..|:.|      |.| ..:..:.:.       :|...
Mouse   200 IIMTVLYWHISRASKSR----IKKEKKEPVANQDPVSPSLVQG-RIVKPNNNN-------MPGGD 252

  Fly   308 SRWRFNSLHD--PPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPT 370
            .....|.:.:  .|....|....:|.:         |.||...|:.:...:.:.|..:|...
Mouse   253 GGLEHNKIQNGKAPRDGGTENCVQGEE---------KESSNDSTSVSAVASNMRDDEITQDE--- 305

  Fly   371 FYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHY----VGTEASFSDTCLGGNVSNNTTTTT 431
                            :.:|...|    ||.......    :.|:....|.|          |.|
Mouse   306 ----------------NTVSTSLG----HSKDDNSRQTCIKIVTKTQKGDAC----------TPT 340

  Fly   432 TNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTK----- 491
            :.||.|.                              ||.||......:......|..||
Mouse   341 STTVELV------------------------------GSSGQNGDEKQNIVARKIVKMTKQPAKK 375

  Fly   492 -----RDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWVNCAINPFI 551
                 |:.|..:|:..::...|..|.|:.|..|:..|. .|.:...:.....|:.::|..|||..
Mouse   376 KPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFC-APCIPNTVWTIGYWLCYINSTINPAC 439

  Fly   552 YAFYNPDFRTAFWRLTCRPICKQK 575
            ||..|..|:..|..|.   :|..|
Mouse   440 YALCNATFKKTFKHLL---MCHYK 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	66/199 (33%)
		TM helix 1	78..101	CDD:410628	11/27 (41%)
		TM helix 2	110..132	CDD:410628	7/21 (33%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	4/22 (18%)
		7tm_GPCRs	<491..563	CDD:475119	20/81 (25%)
		TM helix 6	497..519	CDD:320098	5/21 (24%)
		TM helix 7	531..556	CDD:320098	7/24 (29%)
Chrm2	NP_987076.2	7tmA_mAChR_M2	24..451	CDD:320424	119/512 (23%)
		TM helix 1	25..51	CDD:320424	9/25 (36%)
		TM helix 2	58..84	CDD:320424	7/25 (28%)
		TM helix 3	96..126	CDD:320424	12/29 (41%)
		Important for signaling	120..122		1/1 (100%)
		TM helix 4	138..161	CDD:320424	6/23 (26%)
		TM helix 5	183..212	CDD:320424	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..320		20/141 (14%)
		TM helix 6	380..410	CDD:320424	8/29 (28%)
		TM helix 7	419..444	CDD:320424	7/24 (29%)
		Important for signaling	436..440		2/3 (67%)