Protein Alignment TyrRII and Hrh4

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_694727.1
• Gene: Hrh4 / 225192
• MGIID: 2429635
• Length: 391
• Species: Mus musculus
• Alignment Length: 518
• Identity: 104/518 - (20%)
• Similarity: 184/518 - (35%)
• Gaps: 170/518 - (32%)

  Fly    73 PKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT 137
            |.:..::.|...|:   |||.:||||.:..|.||..:|.|.:||||:|:|||...:|    |||.
Mouse    17 PLAFLMSSFAFAIM---VGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIP----LYIP 74

  Fly   138 G---TWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVV 199
            .   .|.||..:|..|:..|.|||:.|:.::..||.|||.:|:..::|..:.......:..::.|
Mouse    75 HVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAV 139

  Fly   200 WITALSITCPPYL---GWYEVGRHQAEFVDCRYNQNKGYV------VFSAMGSFFIPLTVMLYVY 255
            ||.|..:..|..|   .|    ::.....||    ..|:|      ..:.:..|.:|:..:.|..
Mouse   140 WILAFLVNGPMILASDSW----KNSTNTKDC----EPGFVTEWYILTITMLLEFLLPVISVAYFN 196

  Fly   256 VKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPP 320
            |:|                                          .|     |.|:..:|...|.
Mouse   197 VQI------------------------------------------YW-----SLWKRRALSRCPS 214

  Fly   321 SA---ATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSS 382
            .|   .|:::|.||
Mouse   215 HAGFSTTSSSASGH--------------------------------------------------- 228

  Fly   383 LIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEA 447
             :|.:.::|:...|.:..:.:..|      |.|.......:.:..|...::..|.:......:|:
Mouse   229 -LHRAGVACRTSNPGLKESAASRH------SESPRRKSSILVSLRTHMNSSITAFKVGSFWRSES 286

  Fly   448 KQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWL 512
            ...:|::.:..                                .|..|.|::|.|::.....||.
Mouse   287 AALRQREYAEL--------------------------------LRGRKLARSLAILLSAFAICWA 319

  Fly   513 PFFVYYLLIPFLPRPAVLEDLMFGFT-WIGWVNCAINPFIYAFYNPDFRTAFWRLTCRPICKQ 574
            |:.::.:::...||....:.:.:... |:.|.|..:|||:|...:..|:.|||::.|  :.||
Mouse   320 PYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILC--VTKQ 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	59/203 (29%)
		TM helix 1	78..101	CDD:410628	9/22 (41%)
		TM helix 2	110..132	CDD:410628	11/21 (52%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	4/15 (27%)
		TM helix 5	233..256	CDD:410628	5/28 (18%)
		7tm_GPCRs	<491..563	CDD:475119	18/72 (25%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	7/25 (28%)
Hrh4	NP_694727.1	7tm_GPCRs	16..376	CDD:475119	101/510 (20%)
		TM helix 1	18..42	CDD:410628	9/26 (35%)
		TM helix 2	51..73	CDD:410628	12/25 (48%)
		TM helix 3	88..110	CDD:410628	7/21 (33%)
		TM helix 4	134..150	CDD:410628	4/15 (27%)
		TM helix 5	174..197	CDD:410628	3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..258		4/25 (16%)
		TM helix 6	304..326	CDD:410628	6/21 (29%)
		TM helix 7	339..364	CDD:410628	7/24 (29%)