Protein Alignment TyrRII and Chrm5

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_991352.2
• Gene: Chrm5 / 213788
• MGIID: 109248
• Length: 532
• Species: Mus musculus
• Alignment Length: 550
• Identity: 139/550 - (25%)
• Similarity: 233/550 - (42%)
• Gaps: 106/550 - (19%)

  Fly    72 WPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYI 136
            |......||..|:.|:|:|||.||:::.....:|:||.|.::::||..|.::|...|.......:
Mouse    28 WEVITIAAVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92

  Fly   137 TGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWI 201
            .|.|..|.:.||:|::||.:..:.|:::|..||.|||.::|:||||..||..|| |.:||.:.|:
Mouse    93 MGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKR-AGIMIGLAWL 156

  Fly   202 TALSITCPPYLGW-YEVGRHQAEFVDCRYN-QNKGYVVF-SAMGSFFIPLTVMLYVYVKIGYVLT 263
            .:..:..|..|.| |.||:......:|:.. .::..:.| :|:.:|:||::||..:|.
Mouse   157 VSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYC------- 214

  Fly   264 SRRQRIVRDAYSERTADY-DVDGDNFISE------------SEHYHCTPTKWLPNR---KSRW-- 310
                ||.|:. .:||.|. |:.|.:.::|            ...:.| |...|..|   ::.|
Mouse   215 ----RIYRET-EKRTKDLADLQGSDSVAEVKKRKPAHRTLLRSFFSC-PRPSLAQRVRNQASWSS 273

  Fly   311 -RFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYEL 374
             |.::.....|:.||:.:|...::. :.:.||.|.|:...|.|..             .|.|
Mouse   274 SRRSTSTTGKPTQATDLSADWEKAE-QVTNCSSCPSSEDEAKATT-------------DPVF--- 321

  Fly   375 VEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTT--------- 430
                         .:.||...   ..:| |..:...|.  .:|.:.....||...|
Mouse   322 -------------QVVCKNEA---KESP-GKEFNTQET--KETFVSPRTENNDYDTPKYFLSPGA 367

  Fly   431 -----TTNTVALETNEKLEAEAKQ-------KQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRM 483
                 :...||.:....::|:..|       |.:....||    |.:....:.|...|.:|....
Mouse   368 AHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSF----PVSKDPSTKGLDPHLSHQMTK 428

  Fly   484 PMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPR--PAVLEDLMFGFTWIGWVNCA 546
            ..|:...| :.|.|:||:.::...|..|.|:.:..|:..|..:  |..|..|.:   |:.:||..
Mouse   429 RKRMVLVK-ERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGY---WLCYVNST 489

  Fly   547 INPFIYAFYNPDFRTAFWRLTCRPICKQKR 576
            |||..||..|..||..|..|.   :|:.|:
Mouse   490 INPICYALCNRTFRKTFKLLL---LCRWKK 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	63/194 (32%)
		TM helix 1	78..101	CDD:410628	10/22 (45%)
		TM helix 2	110..132	CDD:410628	6/21 (29%)
		TM helix 3	148..170	CDD:410628	7/21 (33%)
		TM helix 4	194..210	CDD:410628	3/15 (20%)
		TM helix 5	233..256	CDD:410628	7/23 (30%)
		7tm_GPCRs	<491..563	CDD:475119	24/73 (33%)
		TM helix 6	497..519	CDD:320098	6/21 (29%)
		TM helix 7	531..556	CDD:320098	9/24 (38%)
Chrm5	NP_991352.2	7tmA_mAChR_M5	31..>225	CDD:320427	66/206 (32%)
		TM helix 1	32..58	CDD:320427	10/25 (40%)
		TM helix 2	65..91	CDD:320427	6/25 (24%)
		TM helix 3	103..133	CDD:320427	12/29 (41%)
		TM helix 4	145..168	CDD:320427	7/23 (30%)
		TM helix 5	190..219	CDD:320427	10/39 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..290		5/24 (21%)
		7tm_GPCRs	<435..514	CDD:475119	27/85 (32%)
		TM helix 6	441..463	CDD:410628	6/21 (29%)
		TM helix 7	474..499	CDD:410628	10/27 (37%)