DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRII and DRD4

DIOPT Version :10

Sequence 1:NP_650651.1 Gene:TyrRII / 42135 FlyBaseID:FBgn0038541 Length:586 Species:Drosophila melanogaster
Sequence 2:NP_000788.2 Gene:DRD4 / 1815 HGNCID:3025 Length:419 Species:Homo sapiens


Alignment Length:549 Identity:140/549 - (25%)
Similarity:214/549 - (38%) Gaps:133/549 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 GNSNSSDGTLLLIQTSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVV 90
            ||.:::|...||.....|.|.   :.||.||             :|...:.|:...:::|...:.
Human     2 GNRSTADADGLLAGRGPAAGA---SAGASAG-------------LAGQGAAALVGGVLLIGAVLA 50

  Fly    91 GNTLVILAVLTTRRLRTVTNCFVMNLAITDWLVGTCVMPPSVVLYIT-GTWRFGWILCDIWISLD 154
            ||:||.::|.|.|.|:|.||.|:::||..|.|:...|:|..|...:. |.|.....|||..:::|
Human    51 GNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMD 115

  Fly   155 ILLCSGSILSLCAISLDRYLAVTQPLTYSKKRRSKRLALLMILVVWITALSITCPPYLGWYEV-G 218
            ::||:.||.:|||||:||::||..||.|:::..|:| .||:|...|:.:.::..|...|..:| |
Human   116 VMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRR-QLLLIGATWLLSAAVAAPVLCGLNDVRG 179

  Fly   219 RHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDV 283
            |..|.   ||. :::.|||:|::.|||:|..:||.:|......|  :|..:.|.|.....|    
Human   180 RDPAV---CRL-EDRDYVVYSSVCSFFLPCPLMLLLYWATFRGL--QRWEVARRAKLHGRA---- 234

  Fly   284 DGDNFISESEHYHCTPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATG 348
                                |.|.|        .|.|.:.|..|.:..|        ..|.....
Human   235 --------------------PRRPS--------GPGPPSPTPPAPRLPQ--------DPCGPDCA 263

  Fly   349 TAGAGAGAGVVDKTLTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEAS 413
            ....|...|                           .|.. .|....|.:...|.|.........
Human   264 PPAPGLPRG---------------------------PCGP-DCAPAAPSLPQDPCGPDCAPPAPG 300

  Fly   414 FSDTCLGGNVSNNTTTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHN 478
            ......|.|.:              ..:.:.|.|...|...::                      
Human   301 LPPDPCGSNCA--------------PPDAVRAAALPPQTPPQT---------------------- 329

  Fly   479 HHHRMPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLLIPFLPRPAVLEDLMFGFTWIGWV 543
               |...|...|.|:.|..:.|.:|:|..:.||.||||.::.....|..:|...|:...||:|:|
Human   330 ---RRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYV 391

  Fly   544 NCAINPFIYAFYNPDFRTAFWRLTCRPIC 572
            |.|:||.||..:|.:||..| |...|..|
Human   392 NSALNPVIYTVFNAEFRNVF-RKALRACC 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRIINP_650651.1 7tm_GPCRs 78..>270 CDD:475119 69/193 (36%)
TM helix 1 78..101 CDD:410628 6/22 (27%)
TM helix 2 110..132 CDD:410628 8/21 (38%)
TM helix 3 148..170 CDD:410628 10/21 (48%)
TM helix 4 194..210 CDD:410628 3/15 (20%)
TM helix 5 233..256 CDD:410628 10/22 (45%)
7tm_GPCRs <491..563 CDD:475119 27/71 (38%)
TM helix 6 497..519 CDD:320098 9/21 (43%)
TM helix 7 531..556 CDD:320098 11/24 (46%)
DRD4NP_000788.2 7tmA_D4_dopamine_R 38..411 CDD:320434 123/486 (25%)
TM helix 1 38..62 CDD:320434 6/23 (26%)
TM helix 2 69..95 CDD:320434 10/25 (40%)
TM helix 3 108..138 CDD:320434 15/29 (52%)
TM helix 4 150..173 CDD:320434 6/23 (26%)
TM helix 5 189..218 CDD:320434 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..264 10/73 (14%)
4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P 249..312 12/112 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..336 5/43 (12%)
TM helix 6 339..369 CDD:320434 11/29 (38%)
TM helix 7 379..404 CDD:320434 11/24 (46%)

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