Protein Alignment TyrRII and DRD2

DIOPT Version :9

• Sequence 1: NP_001262682.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 147/554 - (26%)
• Similarity: 215/554 - (38%)
• Gaps: 183/554 - (33%)

  Fly    56 GKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRRLRTVTNCFVMNLAITD 120
            ||...|..|.|           ..:..::|.|.|.||.||.:||...:.|:|.||..:::||:.|
Human    27 GKADRPHYNYY-----------ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVAD 80

  Fly   121 WLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAISLDRYLAVTQPLTYSKK 185
            .||.|.|||..|.|.:.|.|:|..|.|||:::||:::|:.|||:|||||:|||.||..|:.|:.:
Human    81 LLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTR 145

  Fly   186 RRSKRLALLMILVVWITALSITCPPYLGWYEVGRHQAEFVDCRYNQNKGYVVFSAMGSFFIPLTV 250
            ..|||...:||.:||:.:.:|:||...|.....:::....      |..:||:|::.||::|..|
Human   146 YSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIA------NPAFVVYSSIVSFYVPFIV 204

  Fly   251 MLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHCTPTKWLPNRKSRWRFNSL 315
            .|.||:||..||..||:|:                                   |.|...|....
Human   205 TLLVYIKIYIVLRRRRKRV-----------------------------------NTKRSSRAFRA 234

  Fly   316 HDPPPSAATNAAAKG---HQSSVKCSKCSKCSSATGTAGAGAGAGVVDKTLTFKHQPTFYELVEV 377
            |       ..|..||   |...:|.  |:....:.|:.                  |.....||.
Human   235 H-------LRAPLKGNCTHPEDMKL--CTVIMKSNGSF------------------PVNRRRVEA 272

  Fly   378 SRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNTTTTTTNTVALETNEK 442
            :|.:..:....:|..       |.|....|.....|
Human   273 ARRAQELEMEMLSST-------SPPERTRYSPIPPS----------------------------- 301

  Fly   443 LEAEAKQKQQQQRSSFDHHH---PHAHHHGSHG---------QQSHHNHHHR------------- 482
                             ||.   |...|||.|.         :..|...|.:
Human   302 -----------------HHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNG 349

  Fly   483 --------MPMRVSTTKRDSKTAKTLTIVMGGLIACWLPFFVYYLL-------IPFLPRPAVLED 532
                    |..|..:.:::.|..:.|.||:|..|.||||||:.::|       ||    |.
Human   350 KTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIP----PV---- 406

  Fly   533 LMFGFTWIGWVNCAINPFIYAFYNPDFRTAFWRL 566
            |...|||:|:||.|:||.||..:|.:||.||.::
Human   407 LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKI 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_001262682.1	7tm_4	82..>212	CDD:304433	59/129 (46%)
		7tm_1	91..>277	CDD:278431	75/185 (41%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	142/541 (26%)
		TM helix 1	37..61	CDD:320435	10/34 (29%)
		TM helix 2	70..92	CDD:320435	10/21 (48%)
		TM helix 3	108..130	CDD:320435	12/21 (57%)
		TM helix 4	154..170	CDD:320435	6/15 (40%)
		TM helix 5	187..210	CDD:320435	9/22 (41%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		39/276 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		13/103 (13%)
		TM helix 6	372..394	CDD:320435	11/21 (52%)
		TM helix 7	405..430	CDD:320435	13/28 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D189663at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920