Protein Alignment TyrRII and ser-7

DIOPT Version :10

• Sequence 1: NP_650651.1
• Gene: TyrRII / 42135
• FlyBaseID: FBgn0038541
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_741730.1
• Gene: ser-7 / 180565
• WormBaseID: WBGene00004780
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 534
• Identity: 128/534 - (23%)
• Similarity: 199/534 - (37%)
• Gaps: 167/534 - (31%)

  Fly    40 TSAAPGGDVMATGAGAGKLGVPSMNSYLVSMAWPKSLAVAVFLVIILVTVVGNTLVILAVLTTRR 104
            |||.|..|:.|.            ...|.|....|:|.....|.:|::|.|||.||.||||..|:
 Worm    19 TSAWPPDDLKAD------------RVQLASFTTGKALLAIAILAMIIMTTVGNALVCLAVLLVRK 71

  Fly   105 LRTVTNCFVMNLAITDWLVGTCVMPPSVVLYITGTWRFGWILCDIWISLDILLCSGSILSLCAIS 169
            |:...|..:::||:.|:.||..|||.:::..:...|..|..:|.::.:.|:.||:.||::|||||
 Worm    72 LKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKWPLGSTMCSVYTTSDLTLCTASIVNLCAIS 136

  Fly   170 LDRYLAVTQPLTYSKKRRSKRLALLMILVVWITA--LSITCPPYLGWYEVGRHQAEFVDCRYNQN 232
            :||||.::.||.||.||.:||: ::.|..|||.|  :||:..........|.:..:...|:...:
 Worm   137 VDRYLVISSPLRYSAKRTTKRI-MMYIACVWIIAAIVSISSHIIANLLNDGTYVDDTGTCQVIPH 200

  Fly   233 KGYVVFSAMGSFFIPLTVMLYVYVKIGYVLTSRRQRIVRDAYSERTADYDVDGDNFISESEHYHC 297
            ..|..::.:.||:.|..:|:.:.:||
 Worm   201 FIYQSYATIISFYAPTFIMVILNIKI--------------------------------------- 226

  Fly   298 TPTKWLPNRKSRWRFNSLHDPPPSAATNAAAKGHQSSVKCSKCSKCSSATGTAGAGAGAGVVDKT 362
                        ||          ||...||:
 Worm   227 ------------WR----------AAKRLAAQ--------------------------------- 236

  Fly   363 LTFKHQPTFYELVEVSRLSSLIHCSAISCKYGGPCMHSTPSGMHYVGTEASFSDTCLGGNVSNNT 427
                           .||.|  ||:::..                       |:....|:.....
 Worm   237 ---------------DRLMS--HCNSVDA-----------------------SERPRNGSAETKD 261

  Fly   428 TTTTTNTVALETNEKLEAEAKQKQQQQRSSFDHHHPHAHHHGSHGQQSHHNHHHRMPMRVSTTKR 492
            ......|:.:...|:..:...:..:.:|...  |.|.|....:.|           |:...|.|.
 Worm   262 FLNEKETIDVPKKERANSTNSRLFKLERKYL--HRPSAFFSAAKG-----------PLIRQTEKS 313

  Fly   493 DSKTAKTLTIVMGGLIACWLPFFVYYLLIPF-LPRPAVLEDLMFGFTWIGWVNCAINPFIYAFYN 556
            :.|..|||.::|...|.||||||:..:...| :..|..|:.|..   |:|:.|..:||.||..||
 Worm   314 ECKARKTLGVIMSVFIICWLPFFILAIFKSFGMWIPDWLDLLAL---WLGYSNSTLNPLIYCKYN 375

  Fly   557 PDFRTAFWR-LTCR 569
            .:||..|.. |.||
 Worm   376 KEFRIPFREMLACR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRII	NP_650651.1	7tm_GPCRs	78..>270	CDD:475119	64/193 (33%)
		TM helix 1	78..101	CDD:410628	11/22 (50%)
		TM helix 2	110..132	CDD:410628	9/21 (43%)
		TM helix 3	148..170	CDD:410628	9/21 (43%)
		TM helix 4	194..210	CDD:410628	7/17 (41%)
		TM helix 5	233..256	CDD:410628	5/22 (23%)
		7tm_GPCRs	<491..563	CDD:475119	28/72 (39%)
		TM helix 6	497..519	CDD:320098	11/21 (52%)
		TM helix 7	531..556	CDD:320098	8/24 (33%)
ser-7	NP_741730.1	7tmA_5-HT7	42..382	CDD:320452	115/490 (23%)
		TM helix 1	43..69	CDD:320452	13/25 (52%)
		TM helix 2	76..102	CDD:320452	9/25 (36%)
		TM helix 3	114..144	CDD:320452	15/29 (52%)
		TM helix 4	156..178	CDD:320452	9/22 (41%)
		TM helix 5	200..229	CDD:320452	9/89 (10%)
		TM helix 6	231..342	CDD:320452	31/196 (16%)
		TM helix 7	350..375	CDD:320452	9/27 (33%)